2-Substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinones as potential anti-inflammatory agents
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Add time:09/26/2019 Source:sciencedirect.com
New anthranilic acid derivatives, 2-substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinone, were synthesized and evaluated for their anti-inflammatory activity against carrageenan-induced oedema in albino rats. The most active member of the series, 3-(4-bromo-2-carboxyphenyl)-2-(2-fluorophenyl)-5-methyl-4-thiazolidinone 6 was compared with phenylbutazone for its relative anti-inflammatory potency and ulcerogenic liability. ED50, cardiovascular and central nervous system effects of 6 were also studied.
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