Cationic Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids in aqueous media

Add time:09/24/2019    Source:sciencedirect.com

An in-situ generated cationic Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acids to α,β-unsaturated carboxylic acids in water was developed and optimized. For most substrates, nearly quantitative yields were given, and the products can be purified by simple washing without column chromatography. The reaction can be scaled up to 1.0 g easily with excellent yields. Also the loading of catalyst can be lowered to 1.0 mol% with modest yields, and the reaction provided a mild and easy way to synthesize β-disubstituted carboxylic acids.

We also recommend Trading Suppliers and Manufacturers of 4-Chlorophenylboronic acid (cas 1679-18-1). Pls Click Website Link as below: cas 1679-18-1 suppliers

Prev:Concentration of 4-methoxy-2-METHYL-2-BUTANETHIOL (cas 1679-09-0) in Spanish virgin olive oils
Next:Catalyst-free Petasis-type reaction: Three-component decarboxylative coupling of boronic acids with proline and salicylaldehyde for the synthesis of alkylaminophenols)