Regular ArticleInhibition Effects of Benactyzine and Drofenine (cas 1679-76-1) on Human Serum Butyrylcholinesterase

Add time:09/24/2019    Source:sciencedirect.com

Benactyzine and Drofenine (cas 1679-76-1) are widely used anticholinergic drugs. Benactyzine is used to treat organophosphate poisoning and drofenine acts on smooth muscle to stop muscle spasms. Both of these drugs are esters. After they enter the bloodstream, they will interact with butyrylcholinesterase (BChE; acylcholine acyl hydrolase: EC 3.1.1.8), which has an ability to hydrolyze a wide variety of esters. Therefore, the kinetic analysis of their inhibitory effects on human serum BChE was examined using butyrylthiocholine as substrate. Both drugs were competitive inhibitors of BChE and the Ki values of benactyzine and drofenine were calculated to be 0.010 ± 0.001 and 0.003 ± 0.000 mM, respectively, using the Systat (version 5.03, 1991) nonlinear regression analysis software package. According to these parameters, drofenine is a more potent competitive inhibitor of BChE than benactyzine.

We also recommend Trading Suppliers and Manufacturers of Drofenine (cas 1679-76-1). Pls Click Website Link as below: cas 1679-76-1 suppliers

Prev:1 - Polyethylene Terephthalate: Blends, Composites, and Nanocomposites – State of Art, New Challenges, and Opportunities
Next:Full Length ArticleA Tripropylene Glycol Diacrylate-based Polymeric Support Ink for Material Jetting)