Synthesis of a new amphiphilic ortho-carborane as a potential BNCT agent: 4-[N,N-formyl-(ortho-carboranylmethyl)-amino]benzoyl-L-glutamic acid

Add time:09/25/2019    Source:sciencedirect.com

A 1,2-dicarba-closo-dodecaboranyl derivative (8) and its disodium salt (9) were prepared from 4-aminobenzoic acid (1). The water solubility and the biological data (toxicity and cell-uptake) of the disodium salt (9) were identified to be enough for clinical trial.

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