Ozonolysis of 2-(1,4-cyclohexadienyl)glycine
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Add time:09/29/2019 Source:sciencedirect.com
Derivatives of 2-(1,4-cyclohexadienyl)glycine were subjected to total ozonolysis. The free esters as well as the N-protected esters tend to cyclize to yield 2-carbethoxy-3-hydroxy pyrrole derivatives. By treatment of the ozonolysis mixture with hydroxylamine or phenylhydrazine heterocyclic derivatives of glycine were obtained. The structure and formation of pyrazolyl and isoxazolyl glycine derivatives is discussed. The structure of N-acetyl-2-(1-phenylpyrazol-3-yl)glycine ethyl ester by X-ray single crystal analysis is reported.
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