Diphenylmethyl ethers: synthesis and histamine H3-receptor antagonist in vitro and in vivo activity

Add time:09/25/2019    Source:sciencedirect.com

New potent histamine H3-receptor antagonists containing an ether group were synthesized from 3-(1H-imidazole-4-yl)propanol and various substituted diphenylmethyl chlorides. Some of the designed ethers showed high activity at histamine H3-receptors under in vitro as well as under in vivo conditions. Their activity at histamine H1- and H2-receptors was also investigated proving a pharmacological H3-H1-antagonistic profile.

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