Digest paperRecent progresses in the synthesis of functionalized isoxazoles

Add time:09/25/2019    Source:sciencedirect.com

Isoxazole is an important pharmacophore that is critical for biological activity. The isoxazole ring ranks 33rd in frequency among the 351 ring systems found in marketed drugs, thus suggesting a great deal of interest in the synthesis of functional isoxazoles. In recent years, various approaches have been developed for the synthesis and functionalization of isoxazoles. This comprehensive survey summarizes the recent new synthetic approaches to functionalized isoxazoles, with particular focus on the last three years with regard to the following reaction types: (1) 1,3-dipolar cycloaddition, (2) condensation, (3) cycloisomerization, and (4) direct functionalization.

We also recommend Trading Suppliers and Manufacturers of ISOXAZOLE, 4-NITRO- (cas 1121-13-7). Pls Click Website Link as below: cas 1121-13-7 suppliers

Prev:The preparation of 3-methyl-4-nitro-5-(2-alkylethenyl)isoxazoles
Next:Short communicationTBAI-catalyzed intramolecular annulation of chalcone oximes toward isoxazoles)