Stannylation in the electrophilic 2- and 4/6-pyrimidine position and the use of Stannylpyrimidines in coupling and Tin-lithium exchange reactions.
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Add time:10/01/2019 Source:sciencedirect.com
2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones were formed from the stannylpyrimidines and acid chlorides, aryl bromides required Pd-catalysis for coupling reaction.
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