Stereoisomers of 4-amino-3-hydroxy-1-cyclohexanecarboxylic acid and 4-amino-3-oxo-1-cyclohexanecarboxylic acid as mimetics of a twisted cis-amide bond

Add time:09/24/2019    Source:sciencedirect.com

Stereoselective synthesis of the title compounds was performed. The relative configuration of methyl t-4-(tert-butoxycarbonylamino)-c-3-hydroxy-r-1-cyclohexanecarboxylate and methyl trans-4-(tert-butoxycarbonylamino)-3-oxo-r-1-cyclohexanecarboxylate was confirmed by X-ray diffraction methods. Analogues of cyclolinopeptide A (CLA) containing these twisted cis-amide bond mimetics were then synthesised.

We also recommend Trading Suppliers and Manufacturers of 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID (cas 1123-28-0). Pls Click Website Link as below: cas 1123-28-0 suppliers

Prev:UV light-mediated decarboxylative cross-Coupling reaction of aryl acetic acids
Next:c-4-Amino-t-3-hydroxy-r-1-cyclohexanecarboxylic acid and cis-4-amino-3-oxo-1-cyclohexanecarboxylic acid—mimetics of dipeptides with a twisted cis-amide bond)