Original communicationGitalin therapy of congestive heart failure in the aged

Add time:09/26/2019    Source:sciencedirect.com

1.1. Gitalin was used successfully in the treatment of congestive heart failure of seventy-seven patients with an average age of 78.4 years.2.2. The initial gitalinizing dose in 155 trials ranged from 2.5 to 22.5 mg., averaging 7.0 mg. The daily maintenance dose ranged from 0.5 to 2.5 mg., averaging 0.92 mg.3.3. Gitalin was generally well tolerated. Fifteen of seventeen patients refractory to other glycosides were adequately controlled with gitalin. Nausea, anorexia, and occasional ventricular premature contractions were the earliest indications of toxicity. No serious toxic effects occurred. No paroxysmal arrhythmias developed in this series despite doses calculated to produce toxicity.4.4. Some differences between the problems of treating young and older patients with congestive heart disease are discussed.5.5. Gitalin is a very useful cardiac glycoside for the treatment of congestive heart failure in elderly patients because of its wide therapeutic range and efficacy.

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