Original communicationClinical studies of gitalin and of digitalis in the treatment of auricular fibrillation

Add time:10/01/2019    Source:sciencedirect.com

A comparative study of the actions of gitalin and digitalis was made in thirty-six ambulant patients with auricular fibrillation.Gitalin acts like digitalis in slowing the ventricular rate and relieving congestive heart failure in patients with auricular fibrillation.Gitalin parallels digitalis in its effect on the R-T transition and T-waves of the electrocardiogram.Gitalin has a persistence of action at least as long as digitalis.Rapid administration of gitalin in eight patients produced prompt and effective slowing of ventricular rates and clinical improvement without the development of toxic symptoms.The average daily maintenance dose of gitalin was 1110 grain; of digitalis, 214 grains, or 112 cat units.Clinically, 1160 grain of gitalin is equivalent to 1 cat unit of digitalis leaves.The daily maintenance dosages of both drugs show considerable variations in different individuals.Toxic reactions to gitalin are the same as to digitalis. They are neither more nor less frequent. With careful administration they should be rare with either drug.Our studies indicate that digitalis can slow ventricular rates in auricular fibrillation in the absence of heart failure, which is contrary to the contention that slowing of the ventricular rate in auricular fibrillation is effected by digitalis only in the presence of heart failure.

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