Concise access to enantiopure (S)- and (R)-α-trifluoromethyl pyroglutamic acids from Ethyl trifluoropyruvate (cas 13081-18-0)-based chiral CF3-oxazolidines (Fox)
-
Add time:09/26/2019 Source:sciencedirect.com
A straightforward synthesis of enantiopure (S)- and (R)-α-Tfm-pyroglutamic acid is reported. The strategy is based on the use of a chiral CF3-hydroxymorpholinone intermediate conveniently obtained from ethyl trifluoropyruvate-based chiral CF3-oxazolidines (Fox). The key step is an oxidative cyclization followed by a reductive cleavage of the (R)-phenylglycinol chiral auxiliary.
We also recommend Trading Suppliers and Manufacturers of Ethyl trifluoropyruvate (cas 13081-18-0). Pls Click Website Link as below: cas 13081-18-0 suppliers
Prev:A facile synthesis of 3-hydroxy-3-(trifluoromethyl)-1H-pyrrol-2(3H)-ones with Brønsted acid-catalyzed condensation–cyclization reactions of β-enamino esters and Ethyl trifluoropyruvate (cas 13081-18-0)
Next:Asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by Pd(II)-SunPhos complex) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Carbonyl-yne reactions of 3,3,3-trifluoropyruvates09/30/2019
- Catalytic and highly enantioselective Friedel–Crafts type reactions of heteroaromatic compounds with trifluoropyruvate and glyoxylate by a dicationic palladium complex09/29/2019
- The unimolecular dissociation of the glyoxylate, pyruvate, trifluoropyruvate, and α-oxobutyrate anions. Decarboxylation vs. decarbonylation of simple α-ketocarboxylates☆09/28/2019
- Highly stereoselective trifluoropyruvate-ene reaction with Δ20(22)-steroidal olefin by chiral Pd2+-catalyst: New type of VDR antagonist for osteocalcin, Δ20(21)-ene product without (dehydro)lactone and lactam motifs10/01/2019
- Asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by Pd(II)-SunPhos complex09/27/2019
- A facile synthesis of 3-hydroxy-3-(trifluoromethyl)-1H-pyrrol-2(3H)-ones with Brønsted acid-catalyzed condensation–cyclization reactions of β-enamino esters and Ethyl trifluoropyruvate (cas 13081-18-0)09/25/2019
-
Health and Chemical more >
-
Related Products
- Ethyl (13-cis)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate
- ethyl (1R,2R)-1-phenyl-2-(trideuteriomethylamino)cyclohex-3-ene-1-carboxylate,hydrochloride
- Ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate hydrochloride
- Ethyl (2,4,6-trimethylbenzoyl) phenylphosphinate
- Ethyl (2-amino-4-hydroxy-6-methyl-5-pyrimidinyl)acetate
- Ethyl (2-bromopropionamido)acetate
- Ethyl (2-cyanoimino-5,6-dichloro-1,2,3,4-tetrahydroquinazolin-3-yl)acetate
- ETHYL (2E,4Z)-DECADIENOATE
- Ethyl (2-hydroxyethyl)dimethyl-ammonium benzilate chloride
- Ethyl (2-mercaptoethyl) carbamate S-ester with O,O-dimethyl phosphorodithioate