A novel one-pot synthesis of 3-acetyl- and 3-benzoylisoxazole derivatives using ammonium cerium nitrate (CAN)

Add time:09/25/2019    Source:infona.pl

The reaction of dipolarophiles (several alkenes and alkynes) with ammonium cerium(IV) nitrate ((NH ₄ ) ₂ Ce(NO ₃ ) ₆ , CAN(IV)) in acetone under reflux gave 3-acetylisoxazole derivatives. In the case of acetophenone, 3-benzoylisoxazole derivatives were obtained. Moreover, it was found that yields of isoxazole derivatives were improved using ammonium cerium(III) nitrate tetrahydrate ((NH ₄ ) ₂ Ce(NO ₃ ) ₅ .4H ₂ O, CAN(III))-formic acid.

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