Michael addition reactions of acetoacetates and malonates with acrylates in water under strongly alkaline conditions

Add time:09/26/2019    Source:infona.pl

Michael addition reactions of acetoacetates and malonates with acrylates in a 5M KOH aqueous solution without using any other catalysts are described. When they are either tert-butyl or benzyl esters, the reaction proceeded very rapidly to afford moderate to high yields of the corresponding bis-Michael adducts that are unexpectedly stable under these conditions.

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