Chiral separation of bavachinin in Fructus Psoraleae and rat plasma by liquid chromatography using permethylated-β-CD as a chiral selector

Add time:09/30/2019    Source:infona.pl

A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation and detection conditions of HPLC were optimized. Chiral bavachinin were separated with the mobile phase of methanol and water (70:30, v/v) at a flow rate of 1.0mL/min. The linear ranges were in the range of 20–1000μg/mL. The detection limits were tested as 4ng/mL and 6ng/mL for (+)-bavachinin and (−)-bavachinin, respectively. The method has been applied to analyze chiral bavachinin in rat plasma. HPLC–MS method was used to test the accuracy.

We also recommend Trading Suppliers and Manufacturers of BAVACHININ A (cas 19879-30-2). Pls Click Website Link as below: cas 19879-30-2 suppliers

Prev:Development of a fully automated on-line solid phase extraction and high-performance liquid chromatography with diode array detection method for the pharmacokinetic evaluation of bavachinin: A study on absolute bioavailability and dose proportionality
Next:BAVACHIN (cas 19879-32-4) and isobavachalcone, acyl-coenzyme A: Cholesterol acyltransferase inhibitors from Psoralea corylifolia)