Green Synthesis of Fused Imidazo[1,2‐a][1,8]naphthyridine Derivatives Catalyzed by DABCO under Solvent‐Free Solid‐State Conditions and Their Biological Evaluation

Add time:09/29/2019    Source:infona.pl

An efficient and eco‐friendly methodology has been developed for the construction of fused imidazo[1,2‐a][1,8]naphthyridine derivatives in the presence of 1,4‐diazabicyclo[2.2.2]octane, and involving various substituted heterocyclic amines with phenacyl bromide under solvent‐free solid‐state condition obtained the corresponding compounds (5a–g, 7a–f) in short reaction time with high yield which is the important features of this protocol. All newly synthesized products were evaluated for their antibacterial and fungal activities. All these compounds displayed good antibacterial and antifungal activity. In predominantly, compounds 7e, 7d, and 5d demonstrate the highest antibacterial and antifungal activities. Furthermore, in silico molecular docking studies results were well complemented to the antimicrobial activity.

We also recommend Trading Suppliers and Manufacturers of Solvent Green 3 (cas 128-80-3). Pls Click Website Link as below: cas 128-80-3 suppliers

Prev:An Efficient One‐Pot, Multicomponent, and Green Solvent Protocol for the Synthesis of Dihydropyridine Derivatives
Next:HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: A study of organic/green solvent and continuous/pulse sonication)