A case of paroxysmal nocturnal dystonia responsive to Cyproheptadine (cas 129-03-3): Is it almost always epileptic?

Add time:10/01/2019    Source:infona.pl

Nocturnal Paroxysmal Dystonia (NPD) is characterized by abnormal dyskinetic movements occur mostly during non-REM sleep. From introducing NPD in early 1980s, most authors have been in favour of an epileptic origin for these sleep-related episodes. Clinical characteristics of NPD including abrupt hypermotor behaviours, automatisms and vocalizations, abnormal EEG findings in some patients and therapeutic response to anti-epileptic drugs persuade clinicians to accept NPD as sleep-related epilepsy with frontal lobe origin but it seems this conclusion may not be true in all cases. We present a young adult patient with refractory NPD who responded to antihistamine cyproheptadine and propose an alternative theory to describe NPD according to the basal ganglia dysregulation. So, in such patients, other therapeutic approach should be reasonably sought.

We also recommend Trading Suppliers and Manufacturers of Cyproheptadine (cas 129-03-3). Pls Click Website Link as below: cas 129-03-3 suppliers

Prev:Quantification of Cyproheptadine (cas 129-03-3) in human plasma by high‐performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study
Next:Preventive effect of Cyproheptadine (cas 129-03-3) hydrochloride in refractory patients with frequent migraine)