Different Contractile Effects of Ergonovine and Methylergonovine in Isolated Human Coronary Arteries

Add time:10/01/2019    Source:infona.pl

Ergonovine maleate (E) and methylergonovine maleate (M) have been equivalently used to provoke coronary vasospasm in patients with variant angina. Large epidemiological studies with these drugs revealed varying incidences of positive results in different patient populations. Head to head comparisons of the test sensitivities and the dose dependencies of their effects are not available. In the present study we directly compared the contractile effects of E and M in isolated human coronary arteries in the presence or absence of the thromboxane analogue U 46619 (U46), since thromboxane potentiates serotonin-induced contractions in human coronary arteries. The arteries were obtained from explanted hearts of patients with dilated cardiomyopathy during heart transplantation. Changes in isometric force were recorded in rings with intact endothelium mounted in organ chambers. The rings were exposed to increasing concentrations of E or M (10 - 9 to 10 - 5 M) in the presence or absence of U46 (10 - 9 M), which itself does not significantly affect coronary tone.Results:Thus E and M are weak vasoconstrictors in quiescent human coronary arteries with comparable potency. However, the drugs differ regarding the potentiation of their effects by thromboxane. Provocation with M may not reveal coronary vasospasm due to thromboxane-induced supersensitivity to serotonin.

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