Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of Vinblastine sulfate (cas 143-67-9)

Add time:09/30/2019    Source:infona.pl

Multidrug resistance (MDR) is one of the major obstacles limiting the efficacy of cancer chemotherapy. Identification of new and effective MDR reversal agents is needed. In this study, the effects of polyoxyethylene 40 stearate (PS40) on MDR were evaluated via the transport of the P-glycoprotein (P-gp) substrate vinblastine sulfate (VBL) through Caco-2 cell monolayers and rat intestine tissue. The effects of PS40 on the antitumor activity of VBL were examined through 3-(4,5)-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay and multidrug-resistant tumor-bearing mice. Results of the transport experiments showed that PS40 reduced VBL efflux. The cytotoxicity of vinblastine to K562/ADR cells was significantly enhanced when the cells were cotreated with 100 or 150 μg/mL PS40. In vivo data revealed that average tumor volume and average tumor weight were significantly less in the VBL+PS40 group than in the VBL group. The inhibition rate for tumor growth was increased from 0.06 (VBL group) to 0.84 (VBL+PS40 group). These results suggest that PS40 may be a potentially useful adjuvant to enhance the therapeutic effects of P-gp substrates.

We also recommend Trading Suppliers and Manufacturers of Vinblastine sulfate (cas 143-67-9). Pls Click Website Link as below: cas 143-67-9 suppliers

Prev:Cisplatin, vinblastine, and hydrazine sulfate in advanced, non-small-cell lung cancer: A randomized placebo-controlled, double-blind phase III study of the cancer and leukemia group B
Next:Highly efficient adsorption of Naphthol Green B and Phenol Red (cas 143-74-8) dye by Combination of Ultrasound wave and Copper‐Doped Zinc Sulfide Nanoparticles Loaded on Pistachio‐Nut Shell)