Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen CORTEXOLONE (cas 152-58-9) 17α-propionate for topic application
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Add time:09/29/2019 Source:infona.pl
CORTEXOLONE (cas 152-58-9)-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.
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- Immobilized Heterologous Rhizopus Oryzae Lipase as an Efficient Catalyst in the Acetylation of CORTEXOLONE (cas 152-58-9)09/30/2019
- CORTEXOLONE (cas 152-58-9) 17α‐propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double‐blind comparative study vs. placebo and tretinoin 0·05% cream09/28/2019