Purified Rutin (cas 153-18-4) and Rutin (cas 153-18-4)‐rich asparagus attenuates disease severity and tissue damage following dextran sodium sulfate‐induced colitis

Add time:09/29/2019    Source:infona.pl

Scope This study investigated the effects of cooked whole asparagus (ASP) versus its equivalent level of purified flavonoid glycoside, Rutin (cas 153-18-4) (RUT), on dextran sodium sulfate (DSS)‐induced colitis and subsequent colitis recovery in mice.Methods and results C57BL/6 male mice were fed an AIN‐93G basal diet (BD), or BD supplemented with 2% cooked ASP or 0.025% RUT for 2 wks prior to and during colitis induction with 2% DSS in water for 7 days, followed by 5 days colitis recovery. In colitic mice, both ASP and RUT upregulated mediators of improved barrier integrity and enhanced mucosal injury repair (e.g. Muc1, IL‐22, Rho‐A, Rac1, and Reg3γ), increased the proportion of mouse survival, and improved disease activity index. RUT had the greatest effect in attenuating DSS‐induced colonic damage indicated by increased crypt and goblet cell restitution, reduced colonic myeloperoxidase, as well as attenuated DSS‐induced microbial dysbiosis (reduced Enterobacteriaceae and Bacteroides, and increased unassigned Clostridales, Oscillospira, Lactobacillus, and Bifidobacterium).Conclusion These findings demonstrate that dietary cooked ASP and its flavonoid glycoside, RUT, may be useful in attenuating colitis severity by modulating the colonic microenvironment resulting in reduced colonic inflammation, promotion of colonic mucosal injury repair, and attenuation of colitis‐associated microbial dysbiosis.

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