Modification of gamma-carboline (cas 244-69-9)s with N-substituted propionamides as a new approach to mitoprotective agents
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Add time:09/30/2019 Source:infona.pl
An approach to the modification of biologically active gamma-carbolines with the N-substituted propionamide fragments by the reaction of N-substituted acrylamides with gamma-carbolines catalyzed by cesium fluoride has been suggested. The compounds synthesized were studied for the influence on the functional characteristics of brain mitochondria, in particular, on the membrane potential, calcium-induced “swelling” and calcium capasity of the rat brain mitochondria.
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