Thiophene sulfoximides: 2,4- and 3,4-di-tert-butyl-1-imino-1,1-dihydrothiophene 1-oxides

Add time:07/11/2019    Source:sciencedirect.com

Preparation of sulfoximide derivatives of monocyclic thiophenes is reported. Treatment of 2,4-di-tert-butylthiophene 1-oxide (4) with N-[(p-toluenesulfonyl)imino]-phenyliodinane (TsN=IPh) in the presence of Cu(MeCN)4PF6 in MeCN at room temperature provided 2,4-di-tert-butyl-1-[(p-toluenesulfonyl)imino]-1,1-dihydrothiophene 1-oxide (8) in 81% yield. Hydrolysis of 8 with concentrated H2SO4 at room temperature furnished 2,4-di-tert-butyl-1-imino-1,1-dihydrothiophene 1-oxide (9) in 89% yield. Optical resolution of a pair of enantiomers of 9 was performed by HPLC on a chiral column and their absolute configuration was determined by an X-ray crystallographic analysis.

We also recommend Trading Suppliers and Manufacturers of 2,4-Di-tert-butylthiophene (cas 33369-81-2). Pls Click Website Link as below: cas 33369-81-2 suppliers

Prev:Synthesis, characterization and DNA-binding studies of 1-cyclohexyl-3-tosylurea and its Ni(II), and Cd(II) complexes
Next:Synthesis of novel N-(3-chloro-4-flurophenyl)-2-(5-((3-(4-hydroxy-2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-1-phenyl-1H-pyrazol-4-yl) methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetamides having anti-inflammatory activity)