Improved synthetic routes to methylene-bridged P-chiral diphosphine ligands via secondary phosphine–boranes

Add time:07/19/2019    Source:sciencedirect.com

Improved methods for the preparation of methylene-bridged diphosphine ligands are described. Both enantiomers of the key intermediate tert-butylmethylphosphine–borane were prepared via resolution or by the conversion of one enantiomer into the opposite enantiomer. The precursor borane complexes of bis(tert-butylmethylphosphino)methane (t-Bu-MiniPHOS), bis((1,1,3,3-tetramethylbutyl)methylphosphino)methane (t-Oct-MiniPHOS), and (tert-butylmethylphosphino)(di-tert-butylphosphino)methane (trichickenfootphos) were prepared in good yields and enantiopure form.

We also recommend Trading Suppliers and Manufacturers of METHYLPHOSPHINE BORANE COMPLEX (cas 14975-23-6). Pls Click Website Link as below: cas 14975-23-6 suppliers

Prev:PH bond activation of primary phosphine-boranes: Access to α-hydroxy and α,α′-dihydroxyphosphine-borane adducts by uncatalyzed hydrophosphination of carbonyl derivatives
Next:Synthesis and structure of ferrocenylmethylphosphines, their borane adducts, and some related derivatives)