Use of the 2,4-dinitrobenzyl protecting group in the synthesis of phosphorodithioate analogues of oligodeoxyribonucleotides
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Add time:07/21/2019 Source:sciencedirect.com
The putative intermediate bis(1,2,4-triazolide) derivative (5) is used in the stepwise synthesis in solution of the phosphorodithioate analogue (10) of thymidylyl-(3′→5′)-thymidylyl-(3′→5′)-thymidine; the 2,4-dinitrobenzyl (Dnb) group is used to protect phosphorodithioate internucleotide linkages.
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