Dealkylation of nucleoside arylmethyl 2-chlorophenyl phosphates: the 2,4-dinitrobenzyl protecting group

Add time:07/20/2019    Source:sciencedirect.com

Following a study of the effect of benzyl substitution on the rates of nucleophilic dealkylation of phosphotriesters, 2-4 dinitrobenzyl is proposed as a temporary protecting group for 3′-terminal phosphodiester functions in oligonucleotide synthesis.

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