Solubility determination and thermodynamic modelling of 2-amino-5-methylthiazole in eleven organic solvents from T = (278.15 to 313.15) K and mixing properties of solutions

Add time:07/19/2019    Source:sciencedirect.com

Solubility of 2-amino-5-methylthiazole in methanol, ethanol, n-propanol, isopropanol, acetone, 2-butanone, acetonitrile, ethyl acetate, toluene, 1,4-dioxane and cyclohexane were determined by using the isothermal saturation method over a temperature range from (278.15 to 313.15) K under atmosphere pressure (101.2 kPa). The solubility of 2-amino-5-methylthiazole in the studied solvents increased with the increase in temperature, and the mole solubility obeyed the following order from high to low in different solvents: methanol > ethyl acetate > acetone > ethanol > 1,4-dioxane > (2-butanone, n-propanol) > isopropanol > acetonitrile > toluene > cyclohexane. The attained solubility data of 2-amino-5-methylthiazole were correlated by using the modified Apelblat equation, λh equation, Wilson model and NRTL model. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 10.66 × 10− 4 and 1.74%, respectively. Furthermore, the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration and reduced excess enthalpy were evaluated.

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