Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4-dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid

Add time:07/19/2019    Source:sciencedirect.com

Synthesis of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylic acid (6–10) and their 1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl] derivatives (11–15) are described. Some of them displayed strong analgesic activity.

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