1 The Search for Antiallergic Drugs for the Treatment of Asthma - Problems in Finding a Successor to Sodium Cromoglycate

Add time:07/20/2019    Source:sciencedirect.com

Publisher SummaryThis chapter discusses the development of compounds of a specific type to be used in the treatment of asthma and associated diseases. Contribution has also been made by other classes of drugs in this therapeutic area—namely, the bronchodilators (β2-adrenoreceptor stimulants, phosphodiesterase inhibitors), ediator antagonists (antihistamines, anticholinergics), and corticosteroids. The drug therapy of asthma and related diseases has been greatly improved during the past several years. Compounds that are claimed to have mast-cell-stabilizing properties, but whose primary mode of action is that of antagonizing histamine at H receptors, have also become available for therapeutic use. Problems in this field of research have been referred to and consist essentially of an incomplete knowledge of the mode of action of sodium cromoglycate, the lack of predictability of activity in animal or in vitro models and in human provocation tests for therapeutic activity, and the difficulties inherent in therapeutic trials in such a variable disease as asthma.

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