Synthesis of unnatural amino acids: (S,S,S)-2-azabicyclo[3.3.0]octane-3-carboxylic acid

Add time:07/17/2019    Source:sciencedirect.com

(S,S,S)-2-Azabicyclo[3.3.0]octane-3-carboxylic acid 1, a structural element of the very potent ACE inhibitor HOE 498, is readily available via a diastereo selective synthesis starting from serine or cystine.

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