Eine einfache diastereoselektive synthese von (1sr,3sr,5sr)-2-azabicyclo [3.3.0] Octan-3-carbonsäure

Add time:07/18/2019    Source:sciencedirect.com

(1SR,3SR,5SR)-2-Azabicyclo [3.3.0] octane-3-carboxylic acid, precursor of the angiotensin-converting-enzyme inhibitor Hoe 498, is easily prepared from 1-chloro-1-cyclopentene-2-carbaldehyde in three steps.

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