Synthesis and cytogenetic studies of structure–biological activity relationship of esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers

Add time:07/18/2019    Source:sciencedirect.com

The esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers have been prepared and their cytogenetic studies of structure–biological activity relationship were evaluated. The cytogenetic effects (sister chromatid exchages (SCEs) induction and proliferation rate indices (PRIs) depression) by o-, m- and p-[N,N-bis(2-chloroethyl)amino] cinnamic acid were also investigated. Among the above compounds tested, those of the m-[N,N-bis(2-chloroethyl)amino] cinnamic acid and of the o-[N,N-bis(2-chloroethyl)amino] cinnamic acid ester of aza-homo-Hecogenin were more active in comparison to the others.

We also recommend Trading Suppliers and Manufacturers of N,N-BIS(2-CHLOROETHYL)-4-METHYLANILINE (cas 1204-68-8). Pls Click Website Link as below: cas 1204-68-8 suppliers

Prev:Versatile reactivity of 3-chloro-2-phenyl-isoindole-1-carbaldehyde: hydrolysis and alkylating rearrangement to 1-amino-4-isochromanones
Next:Enzyme activated anti-tumor agents conjugates of p-Hydroxyaniline mustard (cas 1204-69-9) as substrates for hydrolytic enzymes)