Enzyme activated anti-tumor agents conjugates of p-Hydroxyaniline mustard (cas 1204-69-9) as substrates for hydrolytic enzymes
-
Add time:07/18/2019 Source:sciencedirect.com
The O-phosphate, O-sulphate and O-glucuronide of p-hydroxyaniline mustard were synthesised with the objective that they might be selective anti-tumour agents for tumours with high levels of phosphatase, sulphatase and glucuronidase respectively. This paper shows that the O-phosphate and O-glucuronide can be deconjugated by the appropriate enzymes in vitro to release the rapidly reacting p-hydroxyaniline mustard. The O-sulphate however proved refractory to hydrolysis by all aryl sulphatases tested.
We also recommend Trading Suppliers and Manufacturers of Hydroxyaniline mustard (cas 1204-69-9). Pls Click Website Link as below: cas 1204-69-9 suppliers
Prev:Synthesis and cytogenetic studies of structure–biological activity relationship of esters of Hecogenin and aza-homo-Hecogenin with N,N-bis(2-chloroethyl)aminocinnamic acid isomers
Next:Enzyme activated anti-tumour agents— II. The role of alkaline phosphatase in the release of p-Hydroxyaniline mustard (cas 1204-69-9) from its phosphate conjugate in cells in culture) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- New developments in the use of nitrogen mustard alkylating agents as anticancer drugs07/22/2019
- Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines07/20/2019
- Enzyme activated anti-tumour agents—III. hydrolysis of conjugates of p-Hydroxyaniline mustard (cas 1204-69-9) in aqueous solution07/21/2019
- Enzyme activated anti-tumour agents— II. The role of alkaline phosphatase in the release of p-Hydroxyaniline mustard (cas 1204-69-9) from its phosphate conjugate in cells in culture07/19/2019
