Porcine leumorphin, a putative opioid peptide corresponding to amino acid residues 228–256 of preproenkephalin B has been demonstrated to exist in the porcine neurointermediate pituitary. A recent study on the sequence analysis of genomic DNA of human preproenkephalin B has shown that human leu...
Chagas disease (American trypanosomiasis) is one of the most important parasitic diseases with serious social and economic impacts mainly on Latin America. This work reports the synthesis, in vitro trypanocidal evaluation, cytotoxicity assays, and molecular modeling and SAR/QSAR studies of a new...
α-Substituted N-arylaminoacetals are important building blocks for organic synthesis, which can be synthesized via Mannich reaction by using glyoxal dimethyl acetal as a key precursor. As the acetal fragment was known to be susceptible to acid, in literature methods, the Mannich reaction was pe...
Volatile compounds and non-phenolic metabolites (amino acids, organic acids, and sugars) of aqueous green tea extracts obtained by ultrasonic extraction (UE), agitation extraction (AE), hot water extraction (HWE), and conventional extraction (CE) were determined using SPME-GC–MS and HPLC, respe...
The solubility data of 1,6-Bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionamido]hexane, whose abbreviation is Irganox 1098, in eight pure solvents and two binary solvent mixtures were measured at temperatures ranging from (273.15 to 318.15) K by a static analytical method. The results showed th...
Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (brand name T512) was loaded by mesoporous silica nanoparticles (MSNs) to afford the antioxidant for synthetic ester lubricant oil. Rotary oxygen bomb tests, pressure differential scanning calorimetry and oven oxidation tests were conducted...
New carboxyl-containing o-aminophenols and phenoxazines were synthesized by condensation of 3,5-di-(tert.-butyl)-quinone with p-aminobenzoic and anthranilic acids. Oxidative transformations of the o-aminophenols and intermediate o-iminoquinones occur with the formation of the ESR detected phenox...
Polymorphic adenoma gene 1 (PLAG1) is a member of the pleomorphic adenoma gene family. PLAG family of proteins as a nuclear transcription factor mainly play a role in regulating a variety of important genes in the body. The aim of this study was to examine the association of the PLAG1 polymorphi...
Due to the concern about the negative effects of exposure to sunlight, UV-filters are being introduced in all kind of cosmetic formulas. Wastewater treatment plants are not able to remove and/or degrade them; consequently they find their way into rivers, lakes and oceans. These chemicals are acq...
The reaction of copper(II) chloride dihydrate and 8-hydroxy-2-methylquinoline-7-carboxylic acid (Hhmquin-7-COOH) leads to [Cu(hmquin-7-COOH)2(MeOH)]. The compound has been studied by IR, UV–Vis, EPR spectroscopy and X-ray crystallography. X-ray studies confirm bidentate coordination mode of the...
The reactions of [ReOX3(PPh3)2] (X = Cl, Br) with 8-hydroxyquinoline-7-carboxylic acid (Hhquin-7-COOH) and 8-hydroxy-2-methylquinoline-7-carboxylic acid (Hhmquin-7-COOH) have been examined and [ReOX2(hquin-7-COOH)(PPh3)] and [ReOX2(hmquin-7-COOH)(PPh3)] complexes have been obtained. All the comp...
The faster and more efficient new synthetic methodologies of crystalline hydroxyquinoline carboxylic acids and their fluoro-, thio- and dithioanalogues were elaborated. The FTIR, multinuclear NMR, UV–Vis and single crystal X-ray characteristics of the series of quinoline carboxylic acids have b...
New approaches to the synthesis of selected crystalline hydroxyquinolines and their carboxylic acid analogues were elaborated in this paper with the auxiliary of computational and spectroscopic characterization, such as FTIR, NMR and single crystal X-ray measurements. The experimental data were ...
The pseudotetrahedral complexes of [Cu(PPh3)2(L)], where L=8-hydroxy-2-methylquinoline-7-carboxylic acid (1), 8-hydroxy-2,5-dimethylquinoline-7-carboxylic acid (2) or 5-chloro-8-hydroxy-2-methylquinoline-7-carboxylic acid (3) have been synthesized and structurally characterized by X-ray crystall...
The photophysical behaviours of 2,3,6,7-tetrahydro-8-hydroxy-1H, 5H-benzo[i, j] quinolizine-9-carboxaldehyde (THBQC), a molecule having both the intramolecular excited state donor acceptor charge transfer and six member intramolecular hydrogen bonded proton transfer sites, have been investigated...
Pyridofuroxans are analogous to benzofuroxans; they present similar properties and may be synthesized in similar ways. However, when they are prepared from o-nitropyridinazides, they do not need energy to be synthesized, in contrast to benzofuroxans which require heat or light. In order to under...
[1-(1H-benzimidazol-2-yl)-N-(propan-2-ylidene)methanamine-κ2,N2,N3]dichloridozinc(II) 1, [N-((1H-benzimidazole-2-yl-κN)methyl)-4-(((1H-benzimidazole-2-yl-κN)methyl)imino-κN)-2-methylpentan-2-amine-κN)]chloridozinc(II) chloride dihydrate 2, and tris [(E)-4-(((1H-benzimidazol-2-yl-κN3)methyl...
Neutral sphingomyelinase 2 (nSMase2), a key enzyme in ceramide biosynthesis, is a new therapeutic target for the treatment of neurological disorders and cancer. Using 2,6-dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol (DPTIP), our initial hit compound (IC50 = 30 nM) from nSMase2 scr...
We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP5 + (BMX-001), which is currently in Phase I/II Clinical Trials at Duke University (USA) as a radioprotector of...
The 4-methylthioamphetamine (4-MTA) is a sulphur-containing amphetamine-type stimulant (ATS), which appeared on the illicit market in Europe at the end of 90s. For the purpose of this study, several N-alkyl homologues of 4-MTA, including 4-methylthiomethamphetamine (4-MTMA), 4-methylthioethylamp...