DNA replication and repair are complex processes accomplished by the concerted action of a network of enzymes and proteins. DNA ligases play a crucial role in these processes by catalyzing the nick joining between DNA strands. As compared to normal cells, elevated levels of human DNA ligase I (h...
This research aims to investigate development of corn-oil ester and water mixtures as novel solid-liquid phase change material candidates for chilled and frozen food refrigeration applications. Thermal properties of both water and its mixture with corn-oil ester were tested by DSC and T-history ...
Fatty acid methyl esters (FAMEs), which are commonly used to characterize lipids, have several limitations to conclude on many structures. 3-Pyridylcarbinol esters (3-PCE) are used to characterize fatty acid structures [1], in particular, to identify ring and double bond positions on the carbon ...
As a means of improving nerve tract-tracing in the peripheral and central nervous systems we experimented with two (retrograde) fluorescent emulsions, which we have tentatively named Fluoro-Green (FGr) and Fluoro-Red (FRe), and which we believe possess the following seven advantages: (1) they sh...
N-(6-(2-Methoxy-3-(4-fluorophenylsulfonamido)pyridin-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)acetamide exhibits remarkable anticancer effects and toxicity when orally administrated. In present study, alkylurea moiety replaced the acetamide group in the compound and a series of 1-alkyl-3-(6-(2-m...
Recently, the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) have been considered as promising targets for the treatment of cancer. Herein, we synthesized a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as novel PI3K/mTOR dual inhibitors for cancer the...
Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives using N-chlorosuccinimide and aqueous potassium carbonate has been investigated. Chlorination of 1-(5-nitropyridin-2-yl)guanidine by N-chlorosuccinimide in methanol followed by addition of aqueous potassium carbonate gave rise to cyc...
An efficient synthesis for 1-(pyridin-2-yl)-3-(quinolin-2-yl)imidazo[1,5-a]quinoline (PCIC) is presented. Molecular properties as well as thin film deposition and characterization are reported. With an ionization energy of 5.5 eV estimated from cyclic voltammetry and a quantum yield of 28% as de...
The potential of D-glucuronolactone as a starting material for the synthesis of polyfunctional amino acids is illustrated by its conversion to 2S,3R,4R,5S-trihydroxypipecolic acid, 2R,3R,4R,5S-trihydroxypipecolic acid, 2S,4S,5S-dihydroxypipecolic acid, and bulgecinine.
An iodine-promoted, metal-, base-, and solvent-free cross-coupling reaction was developed for the synthesis of various useful secondary amides via an aryl N-addition reaction of aryl groups to cyano groups. This aryl transfer reaction proceeds with arylhydrazine hydrochlorides serving as the ary...
Publisher SummaryThis chapter deals with the chemistry of benzo[b]thiophene from the beginning of 1952 to June 30, 1968. Benzo[b]thiophene is available in semi-commercial quantities. At times, it is difficult to purchase, but it can be readily synthesized from thiophenol. Benzo[b]thiophenes can ...
A series of N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)acylamides was synthesized and evaluated for binding affinity and intrinsic activity at melatonin receptors. The affinity of each compound for the melatonin receptors was determined by binding studies on cloned human MT...
Publisher SummaryThis chapter discusses the molecular structure and physical properties of benzo[b]thiophenes. Molecular orbital calculations are applied to benzo[b]thiophene derivatives. The spectroscopic analysis of benzo[b]thiophenes is provided. The structures of N-(3-phenyl-2-benzo[b]thieny...
Eight novel heterocyclic bridged phanes of the paraquat type were synthesized by a simple two-step procedure. Starting from furan bridged bis(4,4′-bipyridinium) dication 2 and the corresponding bis(bromomethyl)arenes furanophanes of 4,4′-bipyridine were obtained in moderate to high yields. In ...
We have designed and synthesized a series of novel highly conjugated Donor-π-Acceptor-π-Donor form of unsymmetrical benzo[b]thiophene substituted 1,3,4‑oxadiazole derivatives UBTO-3(a–e) by utilizing Wittig Reaction followed by palladium catalyzed Suzuki cross coupling reaction and characteri...
Methylmercury chloride (CH3HgCl) is an important contaminant found in the environment that exerts highly toxic effects in multiple organs of aquatic animals. Recently, some studies revealed the toxic effects of methylmercury and mercury chloride to the energetic metabolism of rodents. However, p...
A series of 1-[(4′-chlorophenyl)carbonyl-4-(aryl)thiosemicarbazide derivatives 1–25 was synthesized and characterized by spectroscopic techniques such as EI-MS and 1H NMR. All compounds were screened for urease inhibitory activity in vitro and demonstrated excellent inhibitory activity in the ...
The comparative in-vivo disintegration, gastric emptying and bioavailability of 41 mg radiolabeled riboflavin 5′-phosphate sodium capsules administered as a single hard gelatin capsule or as four capsules was evaluated in human subjects. A total of 41 mg of riboflavin 5′-phosphate sodium and 7...
A simple liquid chromatographic method for the simultaneous assay of niacinamide, pyridoxine, thiamine and riboflavin 5′-phosphate sodium in liquid multivitamin formulations is described. A novel aspect of the procedure is the conversion of the riboflavin 5′-phosphate sodium to riboflavin (vit...
The light sensitive compound riboflavin-5′-phosphate (or flavin mononucleotide, FMN) generates reactive oxygen species (ROS) upon photo-irradiation. FMN is required by all flavoproteins because it is a cofactor of biological blue-light receptors. The photochemical effects of FMN after irradiati...