1. Introduction of 3-Bromoanisole
3-Bromoanisole is also named as 1-Bromo-3-methoxybenzene; 3-Methoxy-1-bromobenzene; 3-Methoxybromobenzene; NSC 82293; m-Bromoanisole; m-Bromomethoxybenzene; m-Bromophenyl methyl ether; m-Methoxybromobenzene. 3-Bromoanisole is colorless clear liquid.

2. Properties of 3-Bromoanisole
Melting Point: 2 °C
Boiling Point: 210.5 °C at 760 mmHg 
Flash Point: 93.3 °C
Index of Refraction: 1.539
Molar Refractivity: 40.62 cm³
Molar Volume: 129.6 cm³
Surface Tension: 34.6 dyne/cm 
Enthalpy of Vaporization: 42.86 kJ/mol
Vapour Pressure: 0.278 mmHg at 25 °C
XLogP3: 3
H-Bond Acceptor: 1
Rotatable Bond Count: 1
Exact Mass: 185.968027
MonoIsotopic Mass: 185.968027
Topological Polar Surface Area: 9.2
Heavy Atom Count: 9

3. Structure Descriptors of 3-Bromoanisole
Canonical SMILES: COC1=CC(=CC=C1)Br
InChI: InChI=1S/C7H7BrO/c1-9-7-4-2-3-6(8)5-7/h2-5H,1H3
InChIKey: PLDWAJLZAAHOGG-UHFFFAOYSA-N

4. Safety Information of 3-Bromoanisole

Hazard Codes: Xi
Safety Statements: 23-24/25 
S23:Do not breathe vapour. 
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
F: 8
Hazard Note: Irritant
TSCA: T
HS Code: 29093038 

5. Use of 3-Bromoanisole
3-Bromoanisole is used in organic synthesis.

6. Preparation of 3-bromoanisole
Comprising methoxydenitrating 3-bromonitrobenzene in the presence of a phase-transfer catalyst (PTC), and the preparation of 3-bromonirtobenzene by the bromination of nitrobenzene with bromine in oleum. The methoxydenitration reagent in an alkali metal methoxide, which is selected from sodium methoxide and potassium methoxide. The amount of methoxide used is 1-1.5 mol per mol of 3-bromonitrobenzene. The alkali methoxide can be a pre-prepared solid or it can be prepared in situ, by the reaction of the corresponding alkali hydroxide and methanol. In the case when pre-prepared solid methoxide is used, the effective amount of alkali hydroxide is between 1.2-1.7 mol per mol of 3-bromonitrobenzebe. The reaction temperatures are between about 40 to 80° C., with preference to reaction temperatures of 50 to 55° C. In the case in which methoxide is prepared in situ, the effective amount of alkali hydroxide is between 2.2-2.4 mol per mol of 3-bromonitrobenzene. The reaction temperatures are between about 50 to 80° C. with preference to reaction temperatures of 55 to 65° C.