Basic information
- Name:
Deferoxamine mesylate
- CAS No.:
138-14-7
- Molecular Structure:
- Formula:
- C25H48N6O8.CH4O3S
- Molecular Weight:
- 656.90
- Deleted CAS:
- 35908-62-4,17688-38-9
- Synonyms:
- Deferoxamine mesilate (JP14);Desferal;Prestwick_988;Deferoxamine mesylate (USP);Butanediamide,N'-[5-[[4-[[5-(acetylhydroxyamino) pentyl]amino]-1,4-dioxobutyl]hydroxyamino] pentyl]-N-(5-aminopentyl)-Nhydroxy-,monomethanesulfonate (salt);Desferal (TN);
- EINECS:
- 205-314-3
- Boiling Point:
- 966.9 °C at 760 mmHg
- Flash Point:
- 538.5 °C
- Safety Description:
- 22-24/25 Details
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Chemistry
Molecular Structure of Deferoxamine mesylate (CAS NO.138-14-7):
IUPAC Name: N-[5-[[4-[5-[Acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide ; Methanesulfonic acid
Molecular Weight: 656.78968 [g/mol]
Molecular Formula: C26H52N6O11S
H-Bond Donor: 7
H-Bond Acceptor: 12
EINECS: 205-314-3
Storage temp.: −20 °C
Solubility: H2O: 50 mg/mL
Appearance: white to off-white powder
Flash Point: 538.5 °C
Enthalpy of Vaporization: 152.67 kJ/mol
Boiling Point: 966.9 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25 °C
Classification Code: Antidote [to iron poisoning]; Chelating agent; Drug / Therapeutic Agent; Human Data
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | parenteral | 16gm/kg/34W-I (16000mg/kg) | CARDIAC: PERICARDITIS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE BLOOD: OTHER CHANGES | American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987. |
| man | TDLo | subcutaneous | 143mg/kg/4D-I (143mg/kg) | SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | British Medical Journal. Vol. 291, Pg. 448, 1985. |
| mouse | LD50 | intraperitoneal | 1240mg/kg (1240mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973. |
| mouse | LD50 | intravenous | 273mg/kg (273mg/kg) | Drugs in Japan Vol. 6, Pg. 496, 1982. | |
| mouse | LD50 | oral | 15200mg/kg (15200mg/kg) | Drugs in Japan Vol. 6, Pg. 496, 1982. | |
| mouse | LD50 | subcutaneous | 1280mg/kg (1280mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973. |
| rat | LD50 | intravenous | 330mg/kg (330mg/kg) | Drugs in Japan Vol. 6, Pg. 496, 1982. | |
| rat | LD50 | oral | 17300mg/kg (17300mg/kg) | Drugs in Japan Vol. 6, Pg. 496, 1982. | |
| rat | LD50 | subcutaneous | 5500mg/kg (5500mg/kg) | Drugs in Japan Vol. 6, Pg. 496, 1982. | |
| women | TDLo | subcutaneous | 150mg/kg/4D-I (150mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | British Medical Journal. Vol. 291, Pg. 448, 1985. |
| women | TDLo | unreported | 900mg/kg/30W- (900mg/kg) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | American Journal of Medicine. Vol. 87, Pg. 468, 1989. |
Safety Profile
Safety Information of Deferoxamine mesylate (CAS NO.138-14-7):
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: UG5310000
Poison by intravenous route. Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Human systemic effects: acute pulmonary edema, blood changes, cardiomyopathy, degenerative brain changes, diarrhea, hypermotility, nausea or vomiting, pericarditis, ulceration or bleeding from small intestine, visual field changes. When heated to decomposition it emits toxic fumes of NOx and SOx.
Specification
Deferoxamine mesylate (CAS NO.138-14-7), its Synonyms are Butanediamide, N'-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate ; Desferal methanesulfonate ; Desferrioxamine B mesylate ; Desferrioxamine B methanesulfonate ; Desferrioxamine mesylate ; Desferrioxamine methanesulfonate ; N-(5-(3-((5-Aminopentyl)hydroxycarbamoyl)propionamido)pentyl)-3-((5-(N-hydroxyacetamido)pentyl)carbamoyl)propionohydroxamic acid monomethanesulfonate (salt) .