Basic information
- Name:
L-Cysteine
- CAS No.:
52-90-4
- Molecular Structure:
- Formula:
- C3H7NO2S
- Molecular Weight:
- 121.17
- Deleted CAS:
- 4371-52-2
- Synonyms:
- L-Cysteine Free Base;2-Amino-3-mercapto-, (R)-;L-Cysteine (JAN);L-Cysteine Base/Hcl (mono/anhyd);(2R)-2-amino-3-mercaptopropanoic acid;Valine,3-mercapto-;alpha-Amino-beta-mercaptopropionic acid, L-;alpha-Amino-beta-thiolpropionic acid, L-;L-2-Amino-3-mercaptopropanoic acid;(2R)-2-amino-3-sulfanyl-propanoic acid;Half-cystine;L-2-Amino-3-mercaptopropionic acid;L-Cysteine Base;(+)-2-Amino-3-mercaptopropionic acid;H-Cys-OH;
- EINECS:
- 200-158-2
- Density:
- 1.334 g/cm3
- Melting Point:
- 220 °C
- Boiling Point:
- 293.9 °C at 760 mmHg
- Flash Point:
- 131.5°C
- Solubility:
- 280 g/L (25°C) in water
- Appearance:
- white crystalline powder
- Hazard Symbols:
Xi,
Xn- Risk Codes:
- 36/37/38-20/21/22
- Safety Description:
- 36/37/39-26 Details
- AvailableForms:
- Available commercially as L(+)-cysteine hydrochloride.
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Chemistry
Molecular Structure:
Molecular Formula: C3H7NO2S
Molecular Weight: 121.15
IUPAC Name: L-Cysteine
Synonyms of L-Cysteine (CAS NO.52-90-4): (R)-2-Amino-3-mercaptopropanoic acid ; (R)-Cysteine ; 2-Amino-3-mercaptopropionic acid ; Cisteina ; Cisteinum ; beta-Mercaptoalanine ; alpha-Amino-beta-mercaptopropanoic acid, L- ; L-2-Amino-3-mercaptopropanoic acid
CAS NO: 52-90-4
EINECS: 200-158-2
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 4
Polar Surface Area: 54.84 Å2
Index of Refraction: 1.549
Molar Refractivity: 28.9 cm3
Molar Volume: 90.7 cm3
Surface Tension: 58.9 dyne/cm
Density: 1.334 g/cm3
Flash Point: 131.5 °C
Enthalpy of Vaporization: 58.69 kJ/mol
Boiling Point: 293.9 °C at 760 mmHg
Vapour Pressure: 0.000411 mmHg at 25°C
Melting point: 220 °C (dec.)(lit.)
Alpha: 8.75 o (c=12, 2N HCl)
Storage temp: Store at RT.
Water Solubility: 280 g/L (25 °C)
Sensitive: Air Sensitive
Appearance: White crystalline powder
Stability: Stability Stable, but may be air sensitive. Incompatible with oxidizing agents, bases
Appearance: White crystalline powder
Product Categories of L-Cysteine (CAS NO.52-90-4): API intermediates;Cysteine [Cys, C];Amino Acids;Amino Acids and Derivatives;alpha-Amino Acids;Antioxidant;Biochemistry;Nutritional Supplements;L-Amino Acids;Amino Acids
Uses
L-Cysteine (CAS NO.52-90-4) is a precursor in the food, pharmaceutical, and personal care industries. It is the mainly used for production of flavors. In the field of personal care, cysteine is used for permanent wave applications predominantly in Asia. Again the cysteine is used for breaking up the disulfide bonds in the hair's keratin. Besides, Cysteine is a very popular target for site-directed labeling experiments to investigate biomolecular structure and dynamics.
Production
Biosynthesis of L-Cysteine (CAS NO.52-90-4):
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Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 1400mg/kg (1400mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1251, 1973. |
| mouse | LD50 | intravenous | 1250mg/kg (1250mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1138, 1969. | |
| mouse | LD50 | oral | 660mg/kg (660mg/kg) | Archives of Toxicology. Vol. 41, Pg. 79, 1978. | |
| mouse | LD50 | subcutaneous | 1360mg/kg (1360mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1251, 1973. |
| rat | LD50 | intraperitoneal | 1620mg/kg (1620mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1251, 1973. |
| rat | LD50 | intravenous | 1140mg/kg (1140mg/kg) | Journal of the American College of Toxicology. Vol. 12, Pg. 113, 1993. | |
| rat | LD50 | oral | 1890mg/kg (1890mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Agents and Actions, A Swiss Journal of Pharmacology. Vol. 4, Pg. 125, 1974. |
| rat | LD50 | subcutaneous | 1550mg/kg (1550mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1251, 1973. |
Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Safety Profile
The Hazard Codes of L-Cysteine (CAS NO.52-90-4): 
Xn,Xi
The Risk Statements: 36/37/38-20/21/22
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements: 36/37/39-26
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection. WGK Germany: 3
RTECS: HA1600000
F: 10-23
HS Code: 29309012
Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4°C/39°F.) Store under nitrogen.