Product Name: Prazosin hydrochloride (CAS NO.19237-84-4)

Molecular Formula: C₁₉H₂₂ClN₅O₄
Molecular Weight: 419.86g/mol
IUPAC: [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone hydrochloride
Mol File: 19237-84-4.mol
Einecs: 242-903-4
Appearance: Off-White to Yellow Powder
Melting Point: 277 - 280 °C
Water Solubility: 1 mg/mL, clear, colorless
Enthalpy of Vaporization: 94.28 kJ/mol
Vapour Pressure: 3.4E-16 mmHg at 25°C
Product Categories: Intermediates & Fine Chemicals ; Pharmaceuticals ; Adrenoceptor

 Prazosin hydrochloride (CAS NO.19237-84-4) is a sympatholytic drug used to treat high blood pressure (hypertension). It belongs to the class of alpha-adrenergic blockers, which lower blood pressure by relaxing blood vessels. Specifically, prazosin is selective for the alpha-1 receptors on vascular smooth muscle. These receptors are responsible for the vasoconstrictive action of norepinephrine, which would normally raise blood pressure. By blocking these receptors, prazosin reduces blood pressure. It is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures. This is because the body has reached homeostasis at this abnormally high blood pressure. The blood pressure lowering effect is apparent however when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.
The antihypertensive characteristics of prazosin make it a second-line choice for the treatment of high blood pressure.
Prazosin is also useful in treating urinary hesitancy associated with prostatic hyperplasia by blocking alpha-1 receptors, which control constriction of both the prostate and ureters. Although not a first line choice for either hypertension or prostatic hyperplasia, it is a choice for patients who present with both problems concomitantly.
This medication has shown to be effective in treating severe nightmares in children, associated with PTSD symptoms.Also veterans have been treated successfully at the Oregon VA for sleep disturbance related to PTSD. Doses are lower for this purpose than for control of blood pressure.

Safety Information of Prazosin hydrochloride (CAS NO.19237-84-4):
Hazard Codes: Xn
Risk Statements: 22-36/37/38-62 
22:  Harmful if swallowed 
36:  Irritating to the eyes 
37:  Irritating to the respiratory system 
38:  Irritating to the skin 
 Possible risk of impaired fertility
Safety Statements: 28-36
28:  After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 
36:  Wear suitable protective clothing  

 Prazosin hydrochloride ,its CAS NO. is 19237-84-4,the synonyms is 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazinehydr ; 1-(4Aamino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazinemonohydrochlo ; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-piperazinmonohydro ; 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazolinehydrochloride ; 4-Amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-quinazolinhydrochlori ; CP-12299-1 ; Deprazolin ; Hypovase .