Reference

Preparation of phenoxyethylamine derivatives as sympathetic a-blockers

Preparation of phenoxyethylamine derivatives as sympathetic a-blockers. Ito, Yasuo; Kato, Hideo; Etsuchu, Eiichi; Yagi, Noryuki; Sakurai, Shunichiro (Hokuriku Pharmaceutical Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 03261757 A2 21 Nov 1991 Heisei, 3 pp. (Japan). CODEN: JKXXAF. CLASS: ICM: C07C311-37. ICS: A61K031-18. APPLICATION: JP 90-57974 12 Mar 1990. DOCUMENT TYPE: Patent CA Section: 23 (Aliphatic Compounds) Section cross-reference(s): 1 Phenoxyethylamine deriv. I and its pharmaceutically acceptable acid salts are prepd. as sympathetic a-blockers, useful for treatment of hypertension and dysuria (no data). A mixt. of 1.50 g (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide and 1.22 g 1-(5-fluoro-2-methoxyphenoxy)-2-propanone in MeOH was refluxed for 30 min, then treated with NaBH4 at room temp. for 1 h to give 1.60 g colorless liq., which was crystd.There are some commonly used reagents with their cas registry numbers 139415-57-9 and 112101-81-2 in this article. in Et2O to give 0.36 g (-)-I. The mother liquor was distd. and the residue was recrystd. to give 0.36 g crystal. .