Reference

Toxicology and carcinogenesis studies of 2-mercaptobenzothiazole (CAS No

Toxicology and carcinogenesis studies of 2-mercaptobenzothiazole (CAS No. 149-30-4) in F344/N rats and B6C3F1 mice. (Gavage studies). Dieter, Michael P. (Natl. Toxicol. Program, Research Triangle Park, NC 27709, USA). Natl. Toxicol. Program Tech. Rep. Ser., 332, 172 pp. (English) 1988. CODEN: NTPSE3. ISSN: 0888-8051. DOCUMENT TYPE: Report CA Section: 4 (Toxicology) Under the conditions of these 2-yr gavage studies, there was some evidence of carcinogenic activity of 2-mercaptobenzothiazole for male rats, indicated by increased incidences of mononuclear cell leukemia, pancreatic acinar cell adenomas, adrenal gland pheochromocytomas, and preputial gland adenomas or carcinomas (combined). There was some evidence of carcinogenic activity for female rats, indicated by increased incidences of adrenal gland pheochromoytomas and pituitary gland adenomas. There was no evidence of carcinogenic activity for male mice dosed with 375 or 750 mg/kg. There was equivocal evidence of carcinogenic activity for female mice, indicated by increased incidences of hepatocellular adenomas or carcinomas (combined). Toxicity, e.g. nephropathy and ulcers in rats, and genotoxicity, e.g. chromosomal aberrations and sister chromatid exchanges in CHO cells, were demonstrated.

Interactions between disposable syringes and drugs

Interactions between disposable syringes and drugs. Leaching of a benzothiazole vulcanization accelerator and related compounds. Airaudo, C. B.; Assaf, A.; Gayte-Sorbier, A.; Salmona, G.; Vincent, E. J. (Lab. Bromatol., Diet. Anal. Appl. Expert., Fac. Pharm., Marseille 13385, Fr.). Anal. Chim. Acta, 166, 221-31 (French) 1984. CODEN: ACACAM. ISSN: 0003-2670. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Disposable syringes (3 brands) filled with water very quickly yielded 31 compd. with UV absorption peaks. The rubber plunger seals were identified as the source of contaminant. Their anal. by TLC showed the presence of 2-mercaptobenzothiazole (I) [149-30-4], used as a vulcanization accelerator. The compds. extd. into water were identified by mass spectrometry (electron impact and methane chem. ionization) as I, 2-methylthiobenzothiazole [615-22-5], 2-hydroxybenzothiazole [934-34-9], 2-(2-hydroxyethylthio)benzothiazole [4665-63-8] and 2-(2-hydroxyethoxy)benzothiazole [93968-78-6]. The last 3 compds. were formed during sterilization of the syringes with ethylene oxide [75-21-8]. The role of the precise nature of the vulcanization accelerator in this reaction is briefly described (Zn ions seem to be necessary), as are the anal. interferences resulting from the obsd. phenomena.