Reference

Carminic acid-promoted oxygen radical damage to lipid and carbohydrate

Carminic acid-promoted oxygen radical damage to lipid and carbohydrate. Gutteridge, John M. C.; Quinlan, Gregory J. (Div. Antibiot. Chem., Natl. Inst. Biol. Stand. Control, Hampstead/London NW3 6RB, UK). Food Addit. Contam., 3(4), 289-92 (English) 1986. CODEN: FACOEB. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) The food coloring carminic acid [1260-17-9] redox cycles to produce free radicals. These radicals, in the presence of trace amts. of iron salts, readily damage membrane lipid and degrade the carbohydrate deoxyribose [533-67-5]. Damage to membrane lipid appears to involve mainly org. oxygen radicals such as alkoxy and peroxy radicals, whereas that to deoxyribose implicates the hydroxyl radical formed in a Fenton-type reaction. Antioxidants and iron chelators prevent such damage.

Mitomycin C-induced deoxyribose degradation inhibited by superoxide dismutase

Mitomycin C-induced deoxyribose degradation inhibited by superoxide dismutase. A reaction involving iron, hydroxyl and semiquinone radicals. Gutteridge, John M. C.; Quinlan, Gregory J. 69515-74-8 and 9001-05-2 are also occured in this study.; Wilkins, Stephanie (Div. Antibiot. Chem., Natl. Inst. Biol. Stand. Control, Hampstead/London NW3 6RB, UK). FEBS Lett., 167(1), 37-41 (English) 1984. CODEN: FEBLAL. ISSN: 0014-5793. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Mitomycin C [50-07-7] stimulates deoxyribose [533-67-5] degrdn. with the release of thiobarbituric acid-reactive material under conditions of low O concn. This damage is inhibited by scavengers of the hydroxyl radical [3352-57-6], iron chelators and the specific proteins catalase [9001-05-2] and superoxide dismutase [9054-89-1]. The reactive radical species appears to arise from a Fenton-type sequence in which Fe is reduced by the mitomycin C semiquinone radical [69515-74-8]. .