Detail of "63-05-8"

CAS Number:
63-05-8
Name:
Androst-4-ene-3,17-dione
Molecular Structure:
Formula:
C₁₉H₂₆O₂
Molecular Weight:
286.45
Deleted CAS:
104534-78-3|117598-81-9
Synonyms:
17-Ketotestosterone;3,17-Dioxoandrost-4-ene;4-Androstene-3,17-dione;Androstenedione;Fecundin;NSC 9563;SKF 2170;D4-Androstene-3,17-dione;Androstenedione;4-Androstenedione;
EINECS:
200-554-5
Density:
1.11 g/cm³
Melting Point:
170-171 °C(lit.)
Boiling Point:
431.4 °C at 760 mmHg
Flash Point:
161.1 °C
Appearance:
white to off-white solid
Hazard Symbols:
Xn
Risk Codes:
40
Safety:
22-24/25-36 Details

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Reference

Mechanism of control of LH and FSH secretion by LH-RH and gonadal steroids: Mechanism of control of LH and FSH secretion by LH-RH and gonadal steroids. Labrie, F.; Drouin, J.; Lagace, L.; Ferland, L. (Cent.Hosp., Univ. Laval, Quebec, Que., Can.). Prog. Reprod. Biol., 2(Clin. Reprod. Neuroendocrinol., Int. Semin., 6th), 96-104 (English) 1977. CODEN: PRBIDC. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) In anterior pituitary cells in culture, pretreatment with testosterone (I) [58-22-0] (3 .times. 10-9M) caused a marked inhibition of the LH [9002-67-9] responsiveness to LH-releasing hormone (LH-RH) [9034-40-6]. Incubation of cells with I for 40 h did not affect spontaneous LH release and only slightly inhibited maximal LH release in response to LH-RH. I did not affect LH-RH induced FSH [9002-68-0] release. Decreased LH responsiveness to LH-RH was paralleled by an increased cell LH content. In contrast preincubation with I caused an increase (30%) in total FSH. Dose-response curves for the effect of I, 5.alpha.-dihydrotestosterone (II) [521-18-6], 3.alpha.-androstanediol [1852-53-5], 3.beta.-androstanediol [571-20-0], and .DELTA.4-androstenedione [63-05-8] on LH release in response to LH-RH revealed that all 5 steroids exerted the same maximal inhibitory effect (15-20% of control). II was however more potent in this effect than I, whereas 3.alpha.-androstanediol had a potency intermediate between I and II. Pretreatment with 17.beta.-estradiol (III) [50-28-2] decreased the LH-RH-induced LH release. Apparently, gonadal steroids can regulate FSH and LH secretion at the pituitary level.

Effect of chorionic gonadotropin in vitro on steroidogenesis in cell suspensions from polycystic ovaries: Effect of chorionic gonadotropin in vitro on steroidogenesis in cell suspensions from polycystic ovaries. Marovski, S.; Genkova, P. (Inst. Akush. Ginekol., Tsent. Okhr. Maichinstvoto Detstvoto, Sofia, Bulg.). Probl. Akush. Ginekol., 4, 71-7 (Bulgarian) 1976. CODEN: PAKGAV. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Cultured cells from human polycystic ovaries produced .apprx.2 times more steroids, particularly androstenedione [63-05-8] and testosterone [58-22-0], than cells from normal ovaries; however, estrogen prodn. was similar in both cell cultures. Chorionic gonadotropin [9002-61-3] (10 mIU/mL) stimulated steroidogenesis in both normal and polycystic ovarian cell cultures but the response in the polycystic cell cultures was less than that in normal cell cultures. Apparently no 3 .beta.-ol dehydrogenase deficit or 19-hydroxylase block exists in polycystic ovaries.

Detail of "63-05-8"

Androst-4-ene-3,17-dione

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Reference