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CAS No. 71963-77-4 Density 1.18 g/cm3
Solubility Melting Point 86-89oC
Formula C16H26O5 Boiling Point 357.5 °C at 760 mmHg
Molecular Weight 298.38 . Flash Point 140.5 °C
Transport Information OTH Appearance
Safety Risk Codes
Molecular Structure Molecular Structure of 71963-77-4 (Artemether) Hazard Symbols

Albendazole Oral Suspension;SM 224;Artemetero [INN-Spanish];beta-Dihydroartemisinin methyl ether;Artemether [INN];3,12-Epoxy-12H-pyrano[4,3-j]-1,2- benzodioxepin,decahydro-10-methoxy-3,6,9- trimethyl-,(3R,5aS,6R,8aS,9R,10S,12R,12aR)-;Coartem;Methyl-dihydroartemisinine;Artemetherum [INN-Latin];3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-;beta-Artemether;Methyl-ether-qinghaosu;[3R-(3.alpha.,5a.beta.,6.beta.,8a.beta.,9.alpha.,10.alpha.,12.beta.,12aR*)]-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4.3-j]-1,2-benzodioxepin;Artemisininelactol methyl ether;Artemisinin ,Artemether99%;


Artemether Specification

1. Introduction of Artemether

Artemether is one kind of white crystals or a white, crystalline powder. The chemical name of Artemether is (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin. The Product Categories of this chemical is Antimalarial. Artemether is toxic. It is flammable. It will produce Stimulate smoke when buring. So the storage environment should be ventilate, low-temperature and dry.

2. Properties of Artemether

Physical properties about Artemether are:
(1)Boiling Point: 358 °C; (2)Flash Point: 141 °C; (3)Density: 1.18 g/cm3; (4)Index of Refraction: 1.518; (5)Molar Refractivity: 76.54 cm3; (6)Molar Volume: 252.5 cm3; (7)Surface Tension: 39.9 dyne/cm; (8)XLogP3-AA: 3.1; (9)H-Bond Acceptor: 5; (10)Rotatable Bond Count: 1; (11)Exact Mass: 298.178024; (12)MonoIsotopic Mass: 298.178024; (13)Topological Polar Surface Area: 46.2; (14)Heavy Atom Count: 21.

3. Structure Descriptors of Artemether

(1) Canonical SMILES: CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C;
(2) Isomeric SMILES: C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC)C;
(3) InChI: InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1;

4. Toxicity of Artemether

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 263mg/kg (263mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 2, Pg. 138, 1981.
mouse LD50 oral 1gm/kg (1000mg/kg)   Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. D13, Pg. 280, 1992.
mouse LD50 subcutaneous 390mg/kg (390mg/kg)   Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. D13, Pg. 280, 1992.

5. Safety information of Artemether

Poison by intramuscular route. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

6. Uses of Artemether

Artemether is an antimalarial used for the treatment of multi-drug resistant strains of falciparum malaria. Arteether is the derivative of artemisinin, it is a strong schizonticide and can take rapid control of symptoms by killing plasmodium, it is much more effective than artemisinin and used for the curative treatment of all kinds of malaria, especially for the cerebal malaria , severe malaria and chloroquine-resistant malaria. It is also applied in combination with lumefantrine in clinical treatments of malaria.

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