CAS No.93106-60-6,Enrofloxacin Suppliers

Products Categories

Pharmaceutical (260)
Others (71)
Organic Chemicals (32)
Reagent (13)
Food Additives (9)
Plant Extract (8)
(2)
Materials (2)

Basic Information

Molecular Structure:
CAS No.:	93106-60-6
Name:	Enrofloxacin
Article Data:	17

Formula:	C₁₉H₂₂FN₃O₃
Molecular Weight:	359.4
Synonyms:	1-Cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid;Alsir;BAY-Vp 2674;Baytril;Biofloxavet;CFPQ;Enrocin;Enrofan;Enrogil;Enroxil;N-Ethylciprofloxacin;N'-Ethylciprofloxacin;3-Quinolinecarboxylicacid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-;
EINECS:	618-911-2
Density:	1.385 g/cm³
Melting Point:	225 °C
Boiling Point:	560.5 °C at 760 mmHg
Flash Point:	292.8 °C
Solubility:	Soluble in chloroform. Slightly soluble in water. Also soluble in dilute KOH
Appearance:	Pale yellow crystals
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36/37
PSA:	65.78000
LogP:	2.31850

Synthetic route

: 5308-25-8
4-ethylpiperazine

: 86393-33-1
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.316667h; Solvent; Temperature; Reagent/catalyst; Reflux;	97%
at 150℃; for 0.416667h; Microwave irradiation;	93%
With aluminum tri-bromide In ethanol at 75℃; for 4h; Reagent/catalyst; Solvent; Temperature;	92%

: 1-cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid sodium salt

: 5308-25-8
4-ethylpiperazine

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
With aluminum (III) chloride In i-Amyl alcohol at 140℃; for 8h; Temperature;	91.8%

: 131776-44-8
ditrimethylsilyl N-cyclopropyl-3-(4-ethyl-1-piperazinyl)anilinomethylenemalonate

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
	90%

: 5308-25-8
4-ethylpiperazine

: 86393-33-1
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

A: 7-chloro-1-cyclopropyl-6-(4-ethyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

B: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
In water for 13h; Heating;	A n/a B 89%

...Expand

: 74-96-4
ethyl bromide

: 93107-08-5
ciprofloxacin hydrochloride

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; potassium iodide In water; acetonitrile at 20℃; for 12h;	70%

: 5308-25-8
4-ethylpiperazine

: 98349-24-7
ethyl 2,4,5-trifluorobenzoylacetate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 765-30-0
Cyclopropylamine

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 86483-51-4
ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: acetic anhydride / 2 h / Heating 2: 92 percent / ethanol / 1 h / Ambient temperature 3: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 4: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 5: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme

: 86483-53-6
3-Cyclopropylamino-2-(2,4-dichlor-5-fluorbenzoyl)acrylsaeure-ethylester

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 2: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 3: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme

: 86483-54-7
ethyl 1-cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylate

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 2: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme

: 86393-34-2
2,4-dichloro-5-fluorobenzoyl chloride

: 93106-60-6
enrofloxacin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 62 percent / pyridine / dioxane / 1.) 2 h, room temperature, 2.) 1 h, 70 - 80 deg C. 2: 85 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 3: 92 percent / conc. H2SO4 / H2O; acetic acid / 1.5 h / Heating 4: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme
Multi-step reaction with 7 steps 1: Mg/ethanol, CCl4 / ethanol; toluene / 1.) 0 to -5 deg C, 2.) 12 h, room temperature 2: p-toluenesulfonic acid / H2O / 5 h / Heating 3: acetic anhydride / 2 h / Heating 4: 92 percent / ethanol / 1 h / Ambient temperature 5: 90 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C 6: 93 percent / conc. H2SO4 / H2O / 1.5 h / Heating 7: 86 percent / dimethylsulfoxide / 2.5 h / 140 °C View Scheme
Multi-step reaction with 2 steps 1.1: tributyl-amine / 1 h / 70 °C 1.2: 15 °C / 1520.1 Torr 2.1: cesium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene / 125 - 130 °C 2.2: 8 h / 85 °C View Scheme

Raw Materials

Downstream Products

Total:254 Page 1 of 7 1 2 3 4 5 6 …7 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 93106-60-6

Chemistry

IUPAC Name: 1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid
Molecular Weight: 359.394683 [g/mol]
Molecular Formula: C₁₉H₂₂FN₃O₃
XLogP3: -0.2
H-Bond Donor: 1
H-Bond Acceptor: 7
Index of Refraction: 1.634
Molar Refractivity: 92.8 cm³
Molar Volume: 259.3 cm³
Surface Tension: 62 dyne/cm
Density: 1.385 g/cm³
Flash Point: 292.8 °C
Enthalpy of Vaporization: 88.7 kJ/mol
Boiling Point: 560.5 °C at 760 mmHg
Vapour Pressure: 2.13E-13 mmHg at 25 °C
Water Solubility: 3400 mg/L at 25 °C
Appearance: Pale Yellow Crystals
Melting Point: 225 °C
Classification Code of Enrofloxacin (CAS NO.93106-60-6): Antibacterial [veterinary]; Antineoplastic agents; Drug / Therapeutic Agent; Mutation data
Product Categories: Antibiotics for Research and Experimental Use; Biochemistry; Quinolones (Antibiotics for Research and Experimental Use); Intermediates & Fine Chemicals; Pharmaceuticals; Veterinaries

Uses

Enrofloxacin (CAS NO.93106-60-6) is widely used in the treatment of human disease. It is a bactericidal agent. The bactericidal activity of enrofloxacin is concentration dependent, with susceptible bacteria cell death occurring within 20-30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria and is active in both stationary and growth phases of bacterial replication.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intravenous	200mg/kg (200mg/kg)	VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.
mouse	LD50	oral	4336mg/kg (4336mg/kg)	VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.
rabbit	LD50	oral	500mg/kg (500mg/kg)	VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.
rat	LD50	oral	5gm/kg (5000mg/kg)	VMR, Veterinary Medical Review. Vol. 2, Pg. 87, 1987.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS of Enrofloxacin (CAS NO.93106-60-6): VB1993650

Specification

Enrofloxacin (CAS NO.93106-60-6), its Synonyms are 1,4-Dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinolinecarboxylic acid ; 1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ; BAY VP 2674 ; Enrofloxacine ; Enrofloxacino ; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo- ; 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo- .