12262-49-6

Basic information

• Product Name: Solvent Blue 8
• Synonyms: Solvent Blue 8;7-(dimethylamino)-3-(methylimino)-3h-phenothiazin 3-methochloride;aizen methylene blue bh;aizen methylene blue fz;basic lake blue;Basic turquoise BB;bleu de methylene;C.I.Solvent Blue 8
• CAS NO: 12262-49-6
• Molecular Formula: C16H18ClN3S
• Molecular Weight: 319.85222
• EINECS: 200-515-2
• Product Categories: Solvent Dyestuff
• Mol File: 12262-49-6.mol

Chemical Properties

• Appearance: /
• Water Solubility: 40 g/L (20℃)
• CAS DataBase Reference: Solvent Blue 8(CAS DataBase Reference)
• NIST Chemistry Reference: Solvent Blue 8(12262-49-6)
• EPA Substance Registry System: Solvent Blue 8(12262-49-6)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:; R41:
• Safety Statements: S26:; S39:
• Hazardous Substances Data: 12262-49-6(Hazardous Substances Data)

Usage

Uses

Used in Textile Industry:
Solvent Blue 8 is used as a dye for coloring fabrics in the textile industry. Its ability to produce a range of blue shades makes it a versatile choice for various textile applications.
Used in Plastics and Polymers Industry:
Solvent Blue 8 is used as a colorant for plastics and polymers, providing a vibrant blue color to these materials. Its heat-resistant properties make it suitable for use in various plastic products that may be exposed to high temperatures during processing or use.
Used in Inks and Paints Industry:
Solvent Blue 8 is used as a pigment in the production of inks and paints, offering a stable blue color that is resistant to fading when exposed to light and heat. Its poor light fastness and heat resistance make it less suitable for applications requiring high durability, but it can still be used in certain formulations where these properties are not critical.
Used in Analytical Chemistry:
Solvent Blue 8 can be used as an indicator in analytical chemistry due to its color-changing properties when mixed with different chemicals, such as sodium carbonate and hydrochloric acid. This makes it useful for detecting the presence of specific ions or pH changes in a solution.

Preparation

N1,N1-dimethylbenzene-1,4-diamine in Sodium thiosulfate (had better have with Aluminium sulfate) exist, the Dichromate treatment into sulfur generation sulfonic acid (2 – amino – 5 – dimethylaminobenzene thiosulfate), this product then through Dichromate and N,N-dimethylaniline processing, Into indamine – thio acid, then use Dichromate and Copper sulfate monohydrate (or MnO2) cyclization and oxidation, and finally to Zinc chloride double salt out (2C116H18N3SC1,ZnC1.H2O).

Standard

Light Fastness

Melting point

Stable

ISO

Poor

InChI:InChI=1/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1

Upstream product

• 536-47-0 N,N-dimethyl-1,4-phenylenediamine sulfate 
• 71802-09-0 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide 
• 92-84-2 10H-phenothiazine 
• 124-40-3 dimethyl amine 
• 536-46-9 4-dimethylaminophenylamine dihydrochloride 
• 1249-97-4 [3,7-bis(dimethylamino)phenothiazin-10-yl]phenylmethanone 
• 50-00-0 formaldehyd 
• 1747-90-6 3,11-dinitro-10H-phenothiazine 
• 121-69-7 N,N-dimethyl-aniline 
• 4727-46-2 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide 
• 43035-11-6 2-amino-5-dimethylaminophenylthiosulphonic acid 
• 3763-06-2 1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone 
• 613-11-6 Leuco-Methylenblau 
• 635-76-7 thionine cloride 

Downstream Products

• 613-11-6 Leuco-Methylenblau 
• 635-76-7 thionine cloride 
• 531-53-3 azure A 
• 531-55-5 azure B 
• 531-57-7 Azure C 
• 100-61-8 N-methylaniline 
• 106-50-3 1,4-phenylenediamine 
• 124-38-9 carbon dioxide 
• 7732-18-5 water 
• 95-54-5 1,2-diamino-benzene 
• 98-11-3 benzenesulfonic acid 
• 108-95-2 phenol 
• 108-88-3 toluene 
• 61-54-1 tryptamine 

Relevant articles and documents

AND molecular logic gates based on host-guest complexation operational in live cells

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Hypochlorous Acid Activating MB-O to Release Methylene Blue for Photodegrading of Aβ Aggregates

Amyloid-β (Aβ) aggregates are one of biomarkers of Alzheimer's disease (AD). It is well known that Aβ aggregates display neurotoxicty or cytotoxicity to neurons. Thus, degrading Aβ aggregates is crucial for exploring the treatment of AD. Moreover, the excessive production of HOCl in the AD brain is an important feature of the disease. Herein, a novel compound MB-O based on methylene blue (MB) skeleton was designed and synthesized. The probe MB-O can specifically react with HOCl, releasing the fluorophore MB with strong fluorescence intensity increase. More importantly, the released MB is capable of degrading Aβ aggregates under red light irradiation.

A PROCESS FOR THE PREPARATION OF METHYLENE BLUE

Provided herein is a process for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride: Formula (I). The said process comprises preparing 3,7-dibromophenothiazin-5-ium bromide wet Crude(III) from phenothiazine (II) along promoter, catalyst and brominating agent in presence of organic solvent; preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide (IV) from 3,7-dibromophenothiazin-5-ium bromide; preparing 3,7-bis (Dimethylamino)-phenothiazin-5-ium chloride from 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide and subsequently purifying and removing metal content through metal scavenger from 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (I). The present process eliminates the additional step of ion exchange column in the reaction and provides 99 to 99.5 percentage of product purity.

Selective Imaging of HClO in the Liver Tissue In Vivo Using a Near-infrared Hepatocyte-specific Fluorescent Probe

Liver injury is typified by an inflammatory response. Hypochlorous acid (HClO), an important endogenous reactive oxygen species, is regarded as a biomarker associated with liver injury. Near-infrared (NIR) fluorescent probes with the advantage of deep tissue penetrating and low auto-fluorescence interference are more suitable for bioimaging in vivo. Thus, in this work, we designed and synthesized a novel NIR hepatocyte-specific fluorescent probe named NHF. The probe NHF showed fast response (3 s), large spectral variation, and good selectivity to trace HClO in buffer solution. By employing N-acetylgalactosamine (GalNAc) as the targeting ligand, probe NHF can be actively delivered to the liver tissue of zebrafish and mice. It is important that probe NHF is the first NIR hepatocyte-specific fluorescent probe, which successfully visualized the up-regulation of endogenous HClO in the oxygen-glucose deprivation/reperfusion (OGD/R) model HepG2 cells and dynamically monitored APAP-induced endogenous HClO in the liver tissue of zebrafish and mice.

NOVEL IMPROVED METHOD FOR SYNTHESIZING DIAMINOPHENOTHIAZINE COMPOUNDS

The present invention relates to chemical synthesis and purification. Specifically, the present invention relates to a novel and improved method of synthesizing high purity diaminophenothiazine compounds of Formula I, specifically Methylene Blue and its pharmaceutically acceptable salt or hydrates thereof. The present invention relates to an improved method of synthesizing Methylene Blue compound of higher purities than those achievable by using known methods of synthesis as per the requirements of the international pharmacopoeias like USP and EP.

METHOD FOR PREPARING 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-YLIUM IODIDE

Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and includes the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.

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SYNTHESIS OF A THIOSULFONIC ACID BY A STEP OF PERIODATE MEDIATED OXIDATIVE COUPLING OF A THIOSULFONIC ACID WITH AN ANILINE

The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of For