1333-82-0

Basic information

• Product Name: Chromium(VI) trioxide
• Synonyms: Chromia(CrO₃);Chromic anhydride;Chromic trioxide;Chromiumtrioxide;Chromium(VI) oxide;Chromium(VI) trioxide;Monochromium trioxide;Chromiun(Ⅵ)oxide
• CAS NO: 1333-82-0
• Molecular Formula: CrO₃
• Molecular Weight: 99.9943
• EINECS: 215-607-8
• Mol File: 1333-82-0.mol

Chemical Properties

• Melting Point: 196℃
• Boiling Point: 330 °C
• Flash Point: 250°C
• Appearance: dark red crystals or powder
• Density: 2.7 g/cm³
• Water Solubility: 1660 g/L (20℃)
• CAS DataBase Reference: Chromium(VI) trioxide(CAS DataBase Reference)
• NIST Chemistry Reference: Chromium(VI) trioxide(1333-82-0)
• EPA Substance Registry System: Chromium(VI) trioxide(1333-82-0)

Safety Data

• Hazard Codes: O:Oxidizing agent
• Statements: R24/25:; R26:; R35:; R42/43:; R45:; R46:; R48/23:; R50/53:; R62:
• Safety Statements: S45:; S53:; S60:; S61:
• RIDADR: 1463
• HazardClass: 5.1
• PackingGroup: II
• Hazardous Substances Data: 1333-82-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Production:
Chromium(VI) trioxide is used as a key ingredient in the production of chromium plating, which is essential for various industrial applications. Its strong oxidizing properties make it suitable for this application.
Used in Corrosion Inhibition:
Chromium(VI) trioxide is used as a corrosion inhibitor, protecting materials from degradation due to environmental factors. Its oxidizing nature helps in preventing the formation of rust and other corrosive effects.
Used in Dye and Pigment Manufacturing:
Chromium(VI) trioxide is extensively used in the manufacture of dyes and pigments, where its oxidizing properties contribute to the production of vibrant and stable colors.
Used in Cleaning and Disinfection Applications:
Due to its strong oxidizing properties, Chromium(VI) trioxide is used in various cleaning and disinfection applications, effectively removing dirt, stains, and killing microorganisms.
Used in Synthetic Organic Chemistry:
Chromium(VI) trioxide is used as a reagent in a variety of synthetic organic chemistry reactions, where its oxidizing nature aids in the synthesis of complex organic compounds.

InChI:InChI=1/Cr.3O/q+6;3*-2

Synthetic route

chromium (7440-47-3) + oxygen (80937-33-3) → chromium(VI) oxide (1333-82-0)

Conditions	Yield
In gaseous matrix laser-vaporized Cr atoms; O2 seeded in He; underwent supersonic expansion;

chromium chloride + water (7732-18-5) → chromium(VI) oxide (1333-82-0)

Conditions	Yield
Stage #1: chromium chloride; water With ammonia pH=7.5; Stage #2: at 300℃; for 8h; Calcination;

chromium(VI) oxide (1333-82-0) + 3-methyl-6-benzyloxazolo[4,5-b]pyridin-2(3H)-one (175424-48-3) → 3-methyl-6-benzoyloxazolo[4,5-b]pyridin-2(3H)-one (175424-00-7)

Conditions	Yield
With tert.-butylhydroperoxide In dichloromethane	82%

2-Bromo-4-picoline (4926-28-7) + chromium(VI) oxide (1333-82-0) → 2-bromoisonicotinic acid (66572-56-3)

Conditions	Yield
In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid	82%

3N-HCl + 2-bromo-5-chlorotoluene (14495-51-3) + chromium(VI) oxide (1333-82-0) → 2-bromo-5-chlorobenzaldehyde (174265-12-4)

Conditions	Yield
With sulfuric acid In ethanol; water; acetic anhydride	77%

2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,6-difluoro-2,4,5,6-tetrahydrocyclopenta[c]pyrazole (333995-39-4) + chromium(VI) oxide (1333-82-0) → 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,6-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one (333995-42-9)

Conditions	Yield
In hexane; acetic acid; ethyl acetate	76%

hydrogenchloride (7647-01-0) + 2-methylquinoline (91-63-4) + chromium(VI) oxide (1333-82-0) → quinaldinium chlorochromate

Conditions	Yield
In water at 0℃; for 2.5h;	72%

chromium(VI) oxide (1333-82-0) + 1,11-dihydroxy-3-dodecyne (100991-28-4) → 11-hydroxy-3-dodecynoic acid (87519-39-9)

Conditions	Yield
In hexane; sulfuric acid; water; acetone	68%

pentrinitrol (1607-17-6) + chromium(VI) oxide (1333-82-0) → 2-Nitryloxy-2,2-bis(nitryloxymethyl)propionsaeure (67406-79-5)

Conditions	Yield
With sulfuric acid	60%

2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,5-difluoro-2,4,5,6-tetrahydrocyclopenta[c]pyrazole (333995-54-3) + chromium(VI) oxide (1333-82-0) → 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,5-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one (333995-57-6)

Conditions	Yield
In hexane; acetic acid; ethyl acetate	50%

androstenediol-3,17-diacetate (2099-26-5) + chromium(VI) oxide (1333-82-0) → 3β, 17β-diacetoxyandrost-5-ene-7-one (13209-60-4)

Conditions	Yield
In methanol; CrO3; acetic acid	20%

water (7732-18-5) + chromium(VI) oxide (1333-82-0) → chromic acid (7738-94-5)

chromium(VI) oxide (1333-82-0) + N-(tert-butoxycarbonyl)-3-hydroxypyrrolidine (103057-44-9) → tert-butyl 2-oxopyrrolidine-1-carboxylate (85909-08-6)

Conditions	Yield
With pyridine; acetic anhydride In dichloromethane; ethyl acetate

7-benzyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (499790-78-2) + chromium(VI) oxide (1333-82-0) → 7-benzoyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (499792-53-9)

Conditions	Yield
In acetic anhydride

jones reagent + 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propan-1-ol (350231-40-2) + chromium(VI) oxide (1333-82-0) → 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propanoic acid (350231-41-3)

Conditions	Yield
With sulfuric acid In water; acetone

2-chloro-2'-methoxy-5-nitrobenzhydrol (173736-10-2) + chromium(VI) oxide (1333-82-0) → 2-chloro-2'-methoxy-5-nitrobenzophenone (173736-11-3)

Conditions	Yield
In methanol; dichloromethane; water; acetic acid
In methanol; dichloromethane; water; acetic acid
In methanol; dichloromethane; water; acetic acid
In methanol; dichloromethane; water; acetic acid

3-(4-hydroxytetrahydrofuran-3-yloxy)-4-methoxybenzonitrile + chromium(VI) oxide (1333-82-0) → 3-(tetrahydrofuran-4-on-3-yloxy)-4-methoxybenzonitrile

Conditions	Yield
With pyridine; acetic anhydride In dichloromethane; water

ethyl 3-trifluoromethyl-4-[(4-chloro-2-nitrophenyl)(hydroxy)methyl]1H-pyrazole-5-carboxylate + chromium(VI) oxide (1333-82-0) → ethyl 4-(4-chloro-2-nitrobenzoyl)-3-trifluoromethyl-1H-pyrazole-5-carboxylate

Conditions	Yield
With pyridine In dichioromethane; dichloromethane	1.33 g (82%)

sodium hydrogensulfate monohydrate (10034-88-5) + methyl (1-hydroxymethyl-1,2,3,4-tetrahydronaphthalen-5-yl) oxyacetate + chromium(VI) oxide (1333-82-0) → Methyl (1-formyl-1,2,3,4-tetrahydronaphthalen-5-yl) oxyacetate

Conditions	Yield
With pyridine In dichloromethane

chromium(VI) oxide (1333-82-0) + N-<2-(2-hydroxyethoxy)ethyl>benzamide (124243-65-8) → 2-(2-benzamidoethoxy)-acetic acid (142489-50-7)

Conditions	Yield
In sulfuric acid; acetone	2.5 g (74.7%)

2-acetylamino-3-(2-chlorobenzoyl)-5,6-dihydro-7H-benzo[b]thiophene (114777-54-7) + chromium(VI) oxide (1333-82-0) → 2-acetylamino-3-(2-chlorobenzoyl)-5,6-dihydro-4H-benzo[b]thiophen-7-one

Conditions	Yield
In water

5α-bromo-6β-fluoro-17α-hydroxy-16α-methyl-pregnane-3,20-dione + 5-bromo-6β-fluoro-3β,17-dihydroxy-16-methyl-pregnan-20-one + chromium(VI) oxide (1333-82-0) + isopropyl alcohol (67-63-0) → 6α-fluoro-17α-hydroxy-16α-methyl-4-pregnene-3,20-dione

Conditions	Yield
With hydrogen bromide; sodium acetate; chromic acid In tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid; water; acetic acid; acetone

5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose (23202-83-7, 2592-42-9) + chromium(VI) oxide (1333-82-0) → 5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose (34311-63-2)

Conditions	Yield
With pyridine In dichloromethane

chromium(VI) oxide (1333-82-0) + nimodipin (66085-59-4) → Nimodipine Oxidized (85677-93-6)

Conditions	Yield
In acetic acid
In acetic acid

chromium(VI) oxide (1333-82-0) + N-(6-Phenoxy-5-indanyl)-methansulfonamid (75370-30-8) → N-[1-oxo-6-phenoxyindan-5-yl]methanesulfonamide (75360-85-9)

Conditions	Yield
With acetic anhydride In water; acetic acid

17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5-androstene (81721-19-9) + chromium(VI) oxide (1333-82-0) + tert-butyl alcohol (75-65-0) → 17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5-androsten-7-one (81721-20-2)

Conditions	Yield
With acetic anhydride; acetic acid In tetrachloromethane

α-ethyl-1-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole-5-methanol (119085-08-4) + chloroform (67-66-3) + chromium(VI) oxide (1333-82-0) → 1-[1-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazol-5-yl]-1-propanone

Conditions	Yield
With pyridine In methanol; dichloromethane	2.2 parts (12.3%)

jones reagent + methanoate + chromium(VI) oxide (1333-82-0) + sodium carbonate (497-19-8) + cephalothin (153-61-7) → 3-formyl-7-(thien-2-ylacetamido)-2-cephem-4-carboxylic acid (49769-48-4)

Conditions	Yield
With hydrogenchloride In pyridine; concentrated H2 SO4; water; acetic anhydride; ethyl acetate; acetone

(4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene (39780-02-4) + chromium(VI) oxide (1333-82-0) → 3-methoxy-16,17-seco-estra-1,3,5(10)-trien-17-al (39780-07-9)

Conditions	Yield
In pyridine

jones reagent + 2,3,5-trimethyl-6-(6'-acetoxy-1'-hydroxyhexyl)-1,4-benzoquinone (58186-18-8) + chromium(VI) oxide (1333-82-0) → 2,3,5-trimethyl-6-(6'-acetoxy-1'-oxohexyl)-1,4-benzoquinone (58186-19-9)

Conditions	Yield
In sulfuric acid; acetone

21-acetoxy-11α-hydroxy-6,16α-dimethyl-1,4,6-pregnatriene-3,20-dione (67977-35-9) + chromium(VI) oxide (1333-82-0) → 21-acetoxy-6,16α-dimethyl-1,4,6-pregnatriene-3,11,20-trione (67977-36-0)

Conditions	Yield
With sodium hydrogencarbonate In acetic acid

3-Oxa-1-(tetrahydropyran-2-yloxy)decan-9-ol + chromium(VI) oxide (1333-82-0) → 3-oxa-1-(tetrahydropyran-2-yloxy)decan-9-one

Conditions	Yield
In jones reagent; sulfuric acid; water; isopropyl alcohol; acetone

Upstream product

• 7440-47-3 chromium 
• 80937-33-3 oxygen 
• 16284-59-6 chromium chloride 
• 7732-18-5 water 

Downstream Products

• 7738-94-5 chromic acid 
• 499792-53-9 7-benzoyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one 
• 350231-41-3 3-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]propanoic acid 
• 173736-11-3 2-chloro-2'-methoxy-5-nitrobenzophenone 
• 333995-57-6 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,5-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one 
• 333995-42-9 2-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5,6-difluoro-5,6-dihydrocyclopenta[c]pyrazol-4-one 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 142489-50-7 2-(2-benzamidoethoxy)-acetic acid 
• 175424-00-7 3-methyl-6-benzoyloxazolo[4,5-b]pyridin-2(3H)-one 
• 66572-56-3 2-bromoisonicotinic acid 
• 34311-63-2 5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose 
• 85677-93-6 Nimodipine Oxidized 
• 75360-85-9 N-[1-oxo-6-phenoxyindan-5-yl]methanesulfonamide 
• 81721-20-2 17β-acetoxy-3β-benzoyloxy-15β,16β-methylene-5-androsten-7-one 

Relevant articles and documents

Electronic structure of chromium oxides, CrOn- and CrOn (n=1-5) from photoelectron spectroscopy and density functional theory calculations

A comprehensive theoretical and experimental investigation of CrOn- (n=1-5) and their corresponding neutral species was carried out. Photodetachment photoelectron spectra were obtained for the anions produced from a laser vaporization cluster source at various photon energies. Calculated adiabatic and vertical binding energies of CrOn- showed good agreement with the experimental values. It was shown that theoretical calculations are very helpful in interpretations of the photoelectron spectra of the anions, in understanding the electronic and geometrical structures of their ground and excited states, and chemical bonding for both the anions and the neutral species.

Selective gas-phase catalytic fluorination of 1,1,2,3-tetrachloropropene to 2-chloro-3,3,3-trifluoropropene

For synthesis of 2,3,3,3-tetrafluoropropene, 2-chloro-3,3,3- trifluoropropene (HCFO-1233xf) is an essential intermediate. We here report the catalytic fluorination of 1,1,2,3-tetrachloropropene (4E) to 2-chloro-3,3,3-trifluoropropene (HCFO-1233xf) over fluorinated chromia catalyst modified by Y or La. A highly selective and stable catalyst was achieved over the La promoted fluorinated chromia, where almost 100% 4E conversion and HCFO-1233xf selectivity were obtained for a 96 h TOS. The results of preliminary characterization indicated that surface CrOxFy species and BET area of catalyst were related with the 4E fluorination activity.