10034-88-5

Basic information

• Product Name: Sodium bisulfate monohydrate
• Synonyms: SODIUM BISULFATE, MONOHYDRATE REAGENT;Sulfuric acid, monosodium salt, monohydrate;sodium hydrogen sulfate monohydrate, reagent grade;SODIUMBISULFATE,MONOHYDRATE,CRYSTAL,REAGENT;Sodium bisulfate monohydrate,97%,extra pure,reagent, crystals;SodiuM bisulfate Monohydrate, reagent, crystals, extra pure, 97% 500GR;SodiuM bisulfate Monohydrate, 99%, for analysis;SODIUM HYDROGEN SULFATE MONOHYDRATE GR F
• CAS NO: 10034-88-5
• Molecular Formula: HO₄S*H₂O*Na
• Molecular Weight: 138.08
• EINECS: 231-665-7
• Mol File: 10034-88-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 58 °C
• Boiling Point: 330 °C at 760 mmHg
• Appearance: White/Solid
• Density: 2.103
• Vapor Pressure: 3.35E-05mmHg at 25°C
• Storage Temp.: 5-15°C
• Solubility: 1080g/l
• Water Solubility: 670 g/L
• Sensitive: Moisture Sensitive
• Merck: 14,8586
• CAS DataBase Reference: Sodium bisulfate monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium bisulfate monohydrate(10034-88-5)
• EPA Substance Registry System: Sodium bisulfate monohydrate(10034-88-5)

Safety Data

• Hazard Codes: Xi,C
• Statements: 41-34
• Safety Statements: 24-26-45-36/37/39-27-22
• RIDADR: UN 3260 8/PG 3
• WGK Germany: 1
• RTECS: VZ1870000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 10034-88-5(Hazardous Substances Data)

Usage

Description

Sodium bisulfate monohydrate is an organic compound with chemical formula H3NaO5S. The compound has a characteristic odor and is moderately soluble in water.

Uses

Different sources of media describe the Uses of 10034-88-5 differently. You can refer to the following data:
1. Sodium bisulfate monohydrate is acid soluble and is used as a source of sodium for uses compatible with sulfates. Sulfate compounds are esters or salts of sulfuric acid that are formed by replacing one or both hydrogens with metal. Since most metal sulfate compounds are soluble in water, they are normally used in water treatment.
2. Sodium bisulfate monohydrate (Sodium hydrogen sulfate monohydrate) may be employed as a catalyst in the following studies:Synthesis of n-butyl acetate.Esterification reaction of primary and secondary alcohols with aliphatic carboxylic acids.Synthesis of iso-amyl acetate.Synthesis of herbicide, 2,4-D butylate(butyl 2,4-dichlorophenoxyacetate).

Precaution

Sodium bisulfate monohydrate is hygroscopic, thus may cause burns to eyes and skin. Moreover, it can cause respiratory and digestive tract burns.

Chemical Properties

white adhering crystals

General Description

Sodium bisulfate monohydrate (Sodium hydrogen sulfate monohydrate) is a light yellow-colored crystalline sodium salt.

InChI:InChI=1/Na.H2O4S.H2O/c;1-5(2,3)4;/h;(H2,1,2,3,4);1H2/q+1;;/p-1

Synthetic route

sulfuric acid (7664-93-9) + water (7732-18-5) + sodium chloride (7647-14-5) → sodium hydrogensulfate monohydrate (10034-88-5) + Na hydrogensulfate (7681-38-1)

Conditions	Yield
In water Kinetics; exposure of powdered NaCl to H2SO4 soln. with compn. of NaCl:H2O:H2SO4 of 2:8:1 for 24 h at 85% rel. humidities; not isolated, detn. by Raman spectroscopy;

sulfuric acid (7664-93-9) + water (7732-18-5) + sodium chloride (7647-14-5) → hydrogenchloride (7647-01-0) + sodium hydrogensulfate monohydrate (10034-88-5)

Conditions	Yield
In water Kinetics; exposure of powdered NaCl to H2SO4 soln. with compn. of NaCl:H2O:H2SO4 of 2:20:1 at 85% rel. humidities; not isolated, detn. by Raman spectroscopy;

sulfuric acid (7664-93-9) + water (7732-18-5) + sodium chloride (7647-14-5) → sodium hydrogensulfate monohydrate (10034-88-5)

Conditions	Yield
In sulfuric acid Kinetics; exposure of NaCl with 96 wt% H2SO4 (0.5:1 H2SO4:NaCl) in dry bag; storage in desiccator for several days; exposure to environment of 100% rel. humidities for 40 min; not isolated, detn. by Raman spectroscopy;

Glauber's salt + oxalic acid → sodium hydrogensulfate monohydrate (10034-88-5) + sodium hydrogen oxalate monohydrate (16009-94-2)

Conditions	Yield
In neat (no solvent) byproducts: H2O; mixing oxalic acid and Glauber's salt; completation of reaction after 24 h;;
In not given byproducts: H2O; reaction of Glauber's salt with oxalic acid;;
In neat (no solvent) byproducts: H2O; mixing oxalic acid and Glauber's salt; completation of reaction after 24 h;;

sodium sulfate (7757-82-6) → sodium hydrogensulfate monohydrate (10034-88-5)

Conditions	Yield
In water crystallization from an acidic aq. soln. of Na2SO4 at ambient temperature;;
In water crystallization from an acidic aq. soln. of Na2SO4 at ambient temperature;;

sodium hydrogensulfate monohydrate (10034-88-5) + 1,3-bis-(diphenylphosphino)propane (6737-42-4) + water (7732-18-5) + palladium diacetate (3375-31-3) → [Pd(SO4)(1,3-bis(diphenylphosphino)propane)] (874569-73-0)

Conditions	Yield
In water; acetone acetone soln. of ligand added dropwise to soln. of Pd compd. (1:1), excess NaHSO4 in water added; pptd., stirred for 30 min, filtered off, washed (acetone/water=5/2, Et2O), dried (vac.), elem. anal.;	90%

sodium hydrogensulfate monohydrate (10034-88-5) + trimethylsilyl butyrate (16844-99-8) + ammonium chloride + cyclododecanone (830-13-7) + N-cyclohexyl-cyclohexanamine (101-83-7) → Cyclododecylene acetic acid (78293-77-3, 79616-92-5)

Conditions	Yield
With hydrogenchloride In tetrahydrofuran; n-butyllithium	79%

sodium hydrogensulfate monohydrate (10034-88-5) + 1,11α,15S-tris(tetrahydropyran-2-yloxy)-9α-hydroxy-15-cyclopentyl-16,17,18,19,20-pentanorprost-trans-13-en-6-one → 1,11α,15S-tris(tetrahydropyran-2-yloxy)-15-cyclopentyl-16,17,18,19,20-pentanorprost-trans-13-ene-6,9-dione

Conditions	Yield
With pyridine In dichloromethane	62.6%

sodium hydrogensulfate monohydrate (10034-88-5) + Triisopropoxymethan (4447-60-3) + potassium isopropoxide (6831-82-9) + cyclopentanone (120-92-3) → 1-isopropoxy-1-cyclopentene

Conditions	Yield
In isopropyl alcohol	51%

sodium hydrogensulfate monohydrate (10034-88-5) + 3-amino-3-(pyridin-3-yl)propanoic acid (62247-21-6) + di-tert-butyl dicarbonate (24424-99-5) → 3-[(tert-butoxy)carbonyl]amino-3-(3'-pyridyl)propionic acid

Conditions	Yield
With sodium hydroxide; magnesium sulfate In tetrahydrofuran; water

sodium hydrogensulfate monohydrate (10034-88-5) + 4-Aminomethylpiperidine (7144-05-0) → 1-acetyl-4-aminomethylpiperidine (77445-06-8)

Conditions	Yield
With sodium hydroxide; acetic anhydride; benzaldehyde; triethylamine In water; benzene

sodium hydrogensulfate monohydrate (10034-88-5) + sodium ethanolate (141-52-6) + isobutyraldehyde (78-84-2) + diethyl malonate (105-53-3) → 2-isopropyl-5,5-bis(carboethoxy)-1,3-dioxane (35113-48-5)

Conditions	Yield
With sulfuric acid; trimethyl orthoformate; paraformaldehyde In ethanol

sodium hydrogensulfate monohydrate (10034-88-5) + methyl (1-hydroxymethyl-1,2,3,4-tetrahydronaphthalen-5-yl) oxyacetate + chromium(VI) oxide (1333-82-0) → Methyl (1-formyl-1,2,3,4-tetrahydronaphthalen-5-yl) oxyacetate

Conditions	Yield
With pyridine In dichloromethane

sodium hydrogensulfate monohydrate (10034-88-5) + Dimethoxymethane (109-87-5) + butyraldehyde (123-72-8) → 3,5-diethylpyridine (699-25-2)

Conditions	Yield
In ammonium hydroxide; dichloromethane

sodium hydrogensulfate monohydrate (10034-88-5) + L-arginine (74-79-3) + di-tert-butyl dicarbonate (24424-99-5) → t-butyloxycarbonyl-L-arginine (13726-76-6)

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water; butan-1-ol

sodium hydrogensulfate monohydrate (10034-88-5) + methyl 7-((1R,2S,3R,5S)-5-acetoxy-2-hydroxymethyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoate (61302-47-4) → methyl 7-((1R,2R,3R,5S)-5-acetoxy-2-formyl-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)heptanoate (61302-48-5)

Conditions	Yield
With pyridine In dichloromethane; ethyl acetate; benzene

sodium hydrogensulfate monohydrate (10034-88-5) + 2α-(6-methoxycarbonyl-hex-cis-2-enyl)-3β-hydroxymethyl-4α-(2-tetrahydropyranyloxy)-cyclopentan-1α-ol (61218-09-5) + acetyl chloride (75-36-5) → 2α-(6-methoxycarbonylhex-cis-2-enyl)-3β-acetoxymethyl-4α-(2-tetrahydropyranyloxy)cyclopentan-1α-ol (61218-11-9)

Conditions	Yield
With pyridine In methanol; dichloromethane

sodium hydrogensulfate monohydrate (10034-88-5) + Methyl 9α-hydroxy-11α,15 S-bis(2-tetrahydropyranyloxy)-15-(3-propylcyclopentyl)-16,17,18,19,20-pentanorprosta-cis-5,trans-13-dienoate → Methyl 9-oxo-11α,15S-bis(2-tetrahydropyranyloxy)-15-(3-propylcyclopentyl)-16,17,18,19,20-pentanorprosta-cis-5, trans-13-dienoate

Conditions	Yield
With pyridine In dichloromethane

sodium hydrogensulfate monohydrate (10034-88-5) + 2-(Trimethylsilyl)butansaeure-ethylester (14782-43-5) → (+/-)-ethyl 4-methyl-3-phenylpentanoate (72277-17-9)

Conditions	Yield
With hydrogenchloride; lithium diisopropyl amide; palladium-carbon In tetrahydrofuran; methanol; ethyl acetate

sodium hydrogensulfate monohydrate (10034-88-5) + kaolin → aluminium sodium sulfate

Conditions	Yield
In solid byproducts: SiO2; investigation of solid state react. of kaolin and NaHSO4*H2O by DTA and thermogravimetry (up to 700 °C);; X-ray diffraction;

sodium hydrogensulfate monohydrate (10034-88-5) + kaolin → aluminium sodium sulfate * 1.5 H2O

Conditions	Yield
In solid byproducts: SiO2; investigation of solid state react. of kaolin and NaHSO4*H2O by DTA and thermogravimetry (closed vessel, low temp.);; X-ray diffraction;

sodium hydrogensulfate monohydrate (10034-88-5) + zirconium(IV) sulfate → 4Na(1+)*Zr(4+)*4(SO4)(2-)*3H2O=Na4Zr(SO4)4*3H2O

Conditions	Yield
In water addition of 30 g pure Zr sulfate under stirring to a solution of 57.95 g NaHSO4*H2O in 110 ml H2O at 30°C; increase of temperature to 43°C after 10 minutes, then decrease after 20 minutes to 37°C;; evacuation of the filtrate in vacuum, washing 3 times with 15 ml water at 10°C and drying on air; yield 29 g;;
In water addition of 30 g pure Zr sulfate under stirring to a solution of 57.95 g NaHSO4*H2O in 110 ml H2O at 30°C; increase of temperature to 43°C after 10 minutes, then decrease after 20 minutes to 37°C;; evacuation of the filtrate in vacuum, washing 3 times with 15 ml water at 10°C and drying on air; yield 29 g;;

sodium hydrogensulfate monohydrate (10034-88-5) → sodium sulfate (7757-82-6)

Conditions	Yield
In neat (no solvent) byproducts: H2O; transition point 58.54 °C;;
In neat (no solvent) byproducts: H2O; transition point 58.54 °C;;

sodium hydrogensulfate monohydrate (10034-88-5) + ammonia (7664-41-7) → ammonium sulfate + sodium sulfate (7757-82-6)

Conditions	Yield
In melt
In melt

sodium hydrogensulfate monohydrate (10034-88-5) + zirconium(IV) sulfate → 4Na(1+)*4SO4(2-)*Zr(4+)*11H2O=2Na2SO4*Zr(SO4)2*11H2O

Conditions	Yield
In water evaporation of a solution of 10 g Zr sulfate and 16.8 g NaHSO4 in 40 ml H2O at room temperature over H2SO4 with formation of a transparent syrup;; solidifying on scrapeing with a glass stick; drying on air;;

sodium hydrogensulfate monohydrate (10034-88-5) + hydrous zirconium oxide → 4Na(1+)*4SO4(2-)*Zr(4+)*4H2O=2Na2SO4*Zr(SO4)2*4H2O

Conditions	Yield
In not given addition of freshly precipitated Zr dioxide hydrate to a boiling concentrated solution of NaHSO4;; precipitation on cooling down of Zr sulfate, then of Na-Zr-sulfate, finally precipitation of the excess of hydrogensulfate;;
In not given addition of freshly precipitated Zr dioxide hydrate to a boiling concentrated solution of NaHSO4;; precipitation on cooling down of Zr sulfate, then of Na-Zr-sulfate, finally precipitation of the excess of hydrogensulfate;;

sodium hydrogensulfate monohydrate (10034-88-5) → Na hydrogensulfate (7681-38-1)

Conditions	Yield
In neat (no solvent) heating NaHSO4*H2O to 120°C for 48 h;
In neat (no solvent, solid phase) NaHSO4*H2O heated at 420-440 K for 24 h;

sodium hydrogensulfate monohydrate (10034-88-5) + boric acid (11113-50-1) → 5Na(1+)*BO16S4(5-)

Conditions	Yield
at 399.84℃; for 12h;

boron trioxide + sodium hydrogensulfate monohydrate (10034-88-5) + fuming sulphuric acid → BNaO14S4

Conditions	Yield
at 20℃;

sodium hydrogensulfate monohydrate (10034-88-5) + silica gel (112926-00-8, 7631-86-9) → Na(1+)*HSO4(1-)*SiO2 = NaHSO4*SiO2

Conditions	Yield
In water Heating; Inert atmosphere;
at 20℃; for 0.25h;

Upstream product

• 7757-82-6 sodium sulfate 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 7647-14-5 sodium chloride 

Downstream Products

• 35113-48-5 2-isopropyl-5,5-bis(carboethoxy)-1,3-dioxane 
• 7757-82-6 sodium sulfate 
• 874569-73-0 [Pd(SO₄)(1,3-bis(diphenylphosphino)propane)] 
• 7681-38-1 Na hydrogensulfate 
• 72277-17-9 (+/-)-ethyl 4-methyl-3-phenylpentanoate 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 78293-77-3 Cyclododecylene acetic acid 
• 77445-06-8 1-acetyl-4-aminomethylpiperidine 

Relevant articles and documents

Raman spectroscopy and atomic force microscopy of the reaction of sulfuric acid with sodium chloride

The reaction of NaCl with H2SO4 is investigated using Raman spectroscopy, atomic force microscopy (AFM), and gravimetric analysis. Raman spectra are consistent with the formation of NaHSO4 with no evidence for Na2SO4. The spectra indicate that the phase of NaHSO4 varies with the amount of H2O in the H2SO4. At low H2O concentrations, the reaction produces anhydrous β-NaHSO4, which undergoes a phase change to anhydrous α-NaHSO4 over the course of 18 h. At higher H2O concentrations, anhydrous α-NaHSO4 is formed with small amounts of NaHSO4·H2O. AFM measurements on NaCl (100) show the formation of two distinct types of NaHSO4 structures consistent in shape with α-NaHSO4 and β-NaHSO4. The β-NaHSO4 structures are mobile and move along the NaCl (110) plane until they encounter existing stationary α-NaHSO4 structures whereupon the two forms coalescence to form larger α-NaHSO4 structures. Gravimetry was used to determine the amount of HCl evolved upon exposure to aqueous H2SO4 solutions modeling atmospheric aerosols. At low H2SO4 concentrations, a large percentage of the HCl formed remains dissolved in the H2O. These results indicate that for conditions simulating relative humidities above 40%, the fraction of HCl released from this reaction may be as low as 0.40 ± 0.11.