2835-98-5

Basic information

• Product Name: 6-Amino-m-cresol
• Synonyms: JAROCOL 2M5AP;6-amino-meta-cresol;6-Amino-m-cresol;2-Amino-5-methylphenol;2-AMINO-5-METHYLPHENOL 98%;6-Amino-m-methylphenol;m-Hydroxy-p-toluidine;Phenol, 2-amino-5-methyl-;6-AMINO-M- CRESOL, 4-AMINO- 3- HYDROXYTOLUENE, 2-AMINO-5- METHYLPHENOL, 2- HYDROXY-4- METHYLANILINE
• CAS NO: 2835-98-5
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• EINECS: 220-618-6
• Product Categories: Aromatic Phenols;Phenoles and thiophenoles;Amines;NULL
• Mol File: 2835-98-5.mol

Chemical Properties

• Melting Point: 160-162 °C(lit.)
• Boiling Point: 229.26°C (rough estimate)
• Flash Point: 99.8 °C
• Appearance: Beige to brown crystal powder
• Density: 1.0877 (rough estimate)
• Refractive Index: 1.5380 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.87±0.10(Predicted)
• Water Solubility: soluble
• Stability: Hygroscopic
• BRN: 386144
• CAS DataBase Reference: 6-Amino-m-cresol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-m-cresol(2835-98-5)
• EPA Substance Registry System: 6-Amino-m-cresol(2835-98-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-37/39
• WGK Germany: 1
• RTECS: SJ6090000
• Hazardous Substances Data: 2835-98-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Amino-m-cresol is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to inhibit viral proliferation and its interaction with hemoglobin. This makes it a valuable component in the development of antiviral drugs and other therapeutic agents.
Used in Chemical Synthesis:
6-Amino-m-cresol is used as a key component in the synthesis of tridentate Schiff base ligands and novel non-metallocene catalysts with phenoxy-imine ligands. Its unique chemical properties allow for the creation of new and innovative compounds with potential applications in various industries, including materials science and catalysis.

Purification Methods

Crystallise it from H2O, 50% EtOH, or toluene. [Beilstein

InChI:InChI=1/C7H9NO/c1-5-2-3-6(8)7(9)4-5/h2-4,9H,8H2,1H3

Upstream product

• 700-38-9 2-nitro-5-methylphenol 
• 74993-52-5 O-(3-methylphenyl)hydroxylamine 
• 196497-20-8 (1R,5S,8R)-8-methoxy-3,3-dimethyl-2,4,7-trioxabicyclo[3.3.0]octan-6-one 
• 100-46-9 benzylamine 
• 2101-86-2 p-methylazidobenzene 
• 35605-65-3 4-Methyl-2-hydroxyphenylazoformamid 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 861619-98-9 2-amino-3-bromo-5-methyl-phenol 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 88-44-8 2-Amino-5-methylbenzenesulfonic acid 

Downstream Products

• 117099-26-0 N-(2-hydroxy-4-methylphenyl)furan-2-carboxamide 
• 13429-10-2 N-(2-hydroxy-4-methylphenyl)acetamide 
• 106421-35-6 5-(2-hydroxy-4-methyl-phenylcarbamoyl)-benzene-1,3-disulfonyl chloride 
• 55697-67-1 2-(4-tert-pentyl-phenoxy)-butyric acid-(2-hydroxy-4-methyl-anilide) 
• 62143-66-2 1-benzoylamino-2-benzoyloxy-4-methyl-benzene 
• 103854-30-4 butyric acid-(2-hydroxy-4-methyl-anilide) 
• 854625-32-4 2-(2,4-dinitro-phenoxy)-4-methyl-aniline 
• 301325-96-2 2-(2,4-dinitro-anilino)-5-methyl-phenol 
• 14847-51-9 2-bromo-5-methylphenol 
• 35928-80-4 6-iodo-3-methyl-phenol 
• 62143-67-3 (6-methyl-2-phenyl-benzooxazol-5-yl)-phenyl-methanone 
• 14016-00-3 6-methyl-2-phenylbenzoxazole 
• 25761-27-7 1-(4-Chloro-phenyl)-3-(2-hydroxy-4-methyl-phenyl)-urea 
• 16155-97-8 2-(4-chlorophenyl)-6-methylbenzo[d]oxazole 

Relevant articles and documents

High-Density and Thermally Stable Palladium Single-Atom Catalysts for Chemoselective Hydrogenations

Single-atom catalysts (SACs) have shown superior activity and/or selectivity for many energy- and environment-related reactions, but their stability at high site density and under reducing atmosphere remains unresolved. Herein, we elucidate the intrinsic driving force of a Pd single atom with high site density (up to 5 wt %) under reducing atmosphere, and its unique catalytic performance for hydrogenation reactions. In situ experiments and calculations reveal that Pd atoms tend to migrate into the surface vacancy-enriched MoC surface during the carburization process by transferring oxide crystals to carbide crystals, leading to the surface enrichment of atomic Pd instead of formation of particles. The Pd1/α-MoC catalyst exhibits high activity and excellent selectivity for liquid-phase hydrogenation of substituted nitroaromatics (>99 %) and gas-phase hydrogenation of CO2 to CO (>98 %). The Pd1/α-MoC catalyst could endure up to 400 °C without any observable aggregation of single atoms.

Facile reduction of nitroarenes into anilines and nitroalkanes into hydroxylamines via the rapid activation of ammonia· borane complex by supported gold nanoparticles

Gold nanoparticles supported on titania catalyse, even at a ppm loading level, the quantitative reduction of nitroarenes into anilines and nitroalkanes into alkylhydroxylamines by the ammonia× borane complex. No dehalohalogenation was seen in the case of chloro- or bromonitroarenes, while ester, cyano, or carboxylic acid functionalities also remain intact. The nitroarene to aniline reduction pathway does not require nitrosoarenes as intermediate products. Copyright

Ramoplanin derivatives possessing antibacterial activity

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1,3-Dihydroxybenzene derivatives and colorants containing said compounds

1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) and the dyeing agents for keratin fibers containing these compounds.

Indium Mediated Reduction of Nitro and Azide Groups in the Presence of HCl in Aqueous Media

Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF successfully provided the corresponding amine in high to quantitative yields. Under the some reaction conditions, selective reduction of azide and nitro group in the presence of vinyl group could be accomplished.

Process for the preparation of 2-amino-5-alkyl-phenols

2-Amino-5-alkyl-phenols, which are suitable as intermediates in the production of crop-protection agents or photographic couplers, can be prepared by subjecting 2-amino-5-alkyl-benzenesulphonic acids or their salts to alkaline hydrolysis.

3-substituted para-aminophenols

The invention concerns the use of a 3-substituted para-aminophenol as an oxidation dye precursor for dyeing keratinous fibres, in particular human hair. The 3-substituted para-aminophenol has formula: STR1 where R1 represents alkyl, alkenyl, mono- or polyhydroxyalkyl, nitrile, cyanoalkyl, halogenoalkyl, aminoalkyl or alkoxyalkyl and R2 represents hydrogen, alkyl or mono- or polyhydroxyalkyl, provided that when R2 is hydrogen R1 is not methyl or trifluoromethyl, and to addition salts thereof with an acid. The invention also concerns dye compositions containing compound (I). The invention further concerns novel 3-substituted para-aminophenols.

Keratinous fiber dye composition containing a 2-substituted amino-5-alkylphenol derivative coupler

A keratinous fiber dye composition comprising a developer and a coupler, wherein the coupler is a 2-substituted amino-5-alkylphenol derivative represented by the following formula (1): STR1 wherein the all symbols are defined in the disclosure, is disclosed. The keratinous fiber dye composition imparts a color tone of a high chroma and is excellent in coloring power and fastness.

A NEW CONCISE APPROACH TO THE ENANTIOSELECTIVE SYNTHESIS OF THE HYDROXYAMINO ACID MOIETY OF AI-77-B

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Acid-catalyzed amino-migration of O-phenylhydroxylamines

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