33421-39-5Relevant articles and documents
Organic electrophosphorescent material, preparation method, and OLED device containing the same (by machine translation)
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Paragraph 0064-0069, (2020/04/02)
Is an organic electro-phosphorescent material, a preparation method OLED thereof, and an organic electrophosphorescent material comprising the compound. of Formula I, or Formula II, wherein the compound of Formula III is a red light-emitting material. and the compound of Formula I is a red light-emitting material, of the present invention. II. The organic electrophosphorescent material of the present invention is easily sublimated and dissolved III for mass production . The present invention provides an organic electrophosphorescent material having a structure represented by the following formula: OLED. The organic electrophosphorescent material of the present invention is advantageous; in terms of efficiency. OLED. (by machine translation)
Compound and composition for forming organic film
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Paragraph 0142-0144, (2020/01/08)
The present invention provides a compound which is capable of curing to form an organic film even in an inert gas not only in air atmosphere without forming byproducts, and also forming an organic under layer film that has good dry etching durability in substrate processing, excels in heat resistance and possesses superior gap filling/planarizing characteristics of a pattern formed on a substrate.The compound is shown by the following general formula (1-1), wherein AR1 and AR2 each independently represent an aromatic ring or an aromatic ring that contains at least one nitrogen atom and/or sulfur atom, two AR1s, AR1 and AR2, or two AR2s are optionally bonded with each other; AR3 represents a benzene ring, a naphthalene ring, a thiophene ring, a pyridine ring, or a diazine ring; A represents an organic group; B represents an anionic leaving group; Y represents a divalent organic group; p is 1 or 2; q is 1 or 2; r is 0 or 1; s is 2 to 4; when s = 2, Z represents a single bond, a divalentatom, or a divalent organic group; and when s = 3 or 4, Z represents a trivalent or quadrivalent atom or organic group.
Nitrogen introduction of spirobifluorene to form α-, β-, γ-, and δ-aza-9,9′-spirobifluorenes: New bipolar system for efficient blue organic light-emitting diodes
Wu, Peng,Zhu, Jun,Zhang, Zhen,Dou, Dehai,Wang, Hedan,Wei, Bin,Wang, Zixing
, p. 185 - 191 (2018/04/17)
Four aza-9,9′-spirobifluorenes (aza-SBFs) with nitrogen atom at different positions of one fluorene moiety were synthesized to study the structure-properties relationships. α-Aza-SBF and β-aza-SBF possessed almost completely separated the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), while γ-aza-SBF and δ-aza-SBF showed overlapped HOMO and LUMO orbitals. The aza-SBFs showed excellent bipolar features and good thermal stabilities than those of SBFs. The maximum current efficiencies (CE) of α-, β-, γ-, and δ-aza-SBF-based OLEDs were 28.8, 24.9, 25.5, and 27.2 cd/A, respectively. Compared to the SBF, all of four aza-SBFs showed better devices performances. The CE and power efficiency (PE) of OLED based on α-aza-SBF was 28.8 cd/A and 22.6 lm/W, while the SBF-based OLED was only 12.3 cd/A and 8.2 lm/W. The maximum external quantum efficiency of α-aza-SBF-based OLED was 15.4%, which was 2.5 times than that of the SBF-based one (6.6%) due to introduction of nitrogen improving electron transporting. Novel materials based on these components and their potential applications in organic electronics were expected due to their excellent bipolar features.
A sustainable heterogenized palladium catalyst for Suzuki-Miyaura cross coupling reaction of azaheteroaryl halides in aqueous media
Ganesamoorthy,Muthu Tamizh,Shanmugasundaram,Karvembu
, p. 76 - 85 (2018/03/23)
A unique recyclable Pd catalyst (‘SiO2’-NH2-Pd) for Suzuki-Miyaura coupling reaction of azaheteroaryl halides is developed. The catalytic system is working under mild aqueous condition with low Pd loading and without the use of phosphine ligand. The plausible mechanism is proposed based on the formation of undesired symmetrical biaryl from the coupling reaction of azaheteroaryl chlorides due to the oxidative homocoupling of nucleophilic arylboronic acid. This catalytic system represents an attractive and promising approach for the synthesis of azaheterobiaryls with high product yields. The catalyst has demonstrated an excellent recyclability.
Aza-spirobifluorene derivative and preparation method thereof
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Paragraph 0087-0089, (2017/08/18)
The invention discloses an aza-spirobifluorene derivative. The aza-spirobifluorene derivative is characterized by having a structural formula as shown in the specification, wherein only one of X1, X2, X3 and X4 is a nitrogen atom, and the other three are carbon atoms; and R is an aromatic or heterocyclic aromatic ring containing 6-60 carbon atoms. The aza-spirobifluorene derivative disclosed by the invention can be used as an illuminant material; the aza-spirobifluorene derivative can be independently used as an illuminating layer or doped dye for illuminating or can be formed into an exciplex with the other materials for illuminating; the aza-spirobifluorene derivative also has a carrier transporting capacity; and a group has a hole transmitting capacity and an electron transmitting capacity. The aza-spirobifluorene derivative provided by the invention can be prepared into an excellent amorphous film according to vacuum evaporation or solution methods (spin coating, printing, and the like). The aza-spirobifluorene derivative also has higher thermal stability and photo-stability.
Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen
Liu, Kun-Ming,Zhang, Rui,Duan, Xin-Fang
supporting information, p. 1593 - 1598 (2016/02/09)
A room temperature phosphine or NHC ligand-free cobalt-catalyzed arylation of (hetero)aromatic acids has been developed. It involves an oxidative cross-coupling between carboxylate and aryl titanate reagents using oxygen as an oxidant, and the arylation at the position ortho, meta and para to the carboxylic acid group could all be achieved. As application, various (hetero)aromatic acids including xenalipin, tafamidis and the key intermediate for a cardioprotective compound have been efficiently synthesized.
9-Hydroxyazafluorenes and their use in thrombin inhibitors
Stauffer, Kenneth J.,Williams, Peter D.,Selnick, Harold G.,Nantermet, Philippe G.,Newton, Christina L.,Homnick, Carl F.,Zrada, Matthew M.,Lewis, S. Dale,Lucas, Bobby J.,Krueger, Julie A.,Pietrak, Beth L.,Lyle, Elizabeth A.,Singh, Rominder,Miller-Stein, Cynthia,White, Rebecca B.,Wong, Bradley,Wallace, Audrey A.,Sitko, Gary R.,Cook, Jacquelyn J.,Holahan, Marie A.,Stranieri-Michener, Maria,Leonard, Yvonne M.,Lynch Jr., Joseph J.,McMasters, Daniel R.,Yan, Youwei
, p. 2282 - 2293 (2007/10/03)
Optimization of a previously reported thrombin inhibitor, 9-hydroxy-9-fluorenylcarbonyl-L-prolyl-trans-4-aminocyclohexylmethylamide (1), by replacing the aminocyclohexyl P1 group provided a new lead structure, 9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-aminomethyl-5-chlorobenzylamide (2), with improved potency (Ki = 0.49 nM for human thrombin, 2× APTT = 0.37 μM in human plasma) and pharmacokinetic properties (F = 39%, iv T1/2 = 13 h in dogs). An effective strategy for reducing plasma protein binding of 2 and improving efficacy in an in vivo thrombosis model in rats was to replace the lipophilic fluorenyl group in P3 with an azafluorenyl group. Systematic investigation of all possible azafluorenyl P3 isomers and azafluorenyl-N-oxide analogues of 2 led to the identification of an optimal compound, 3-aza-9-hydroxyfluoren-9(R)-ylcarbonyl-L-prolyl-2-aminomethyl-5- chlorobenzylamide (19b), with high potency (Ki = 0.40 nM, 2× APTT = 0.18 μM), excellent pharmacokinetic properties (F = 55%, T 1/2 = 14 h in dogs), and complete efficacy in the in vivo thrombosis model in rats (inhibition of FeCl3-induced vessel occlusions in six of six rats receiving an intravenous infusion of 10 μg/kg/min of 19b). The stereochemistry of the azafluorenyl group in 19b was determined by X-ray crystallographic analysis of its N-oxide derivative (23b) bound in the active site of human thrombin.
Identification of a novel antifungal agent based on a pharmacophoric group in cryptolepine
Mardenborough, Leroy G.,Fan, Pingchen C.,Ablordeppey, Seth Y.,Nimrod, Alison,Clark, Alice M.
, p. 118 - 132 (2007/10/03)
Though its mechanism of action is not yet known, cryptolepine (1) possesses desirable properties to serve as a lead in developing novel antifungal agents. Several analogues of cryptolepine were synthesized in order to identify the pharmacophoric groups present in the molecule. Rational modification of the structure of cryptolepine has resulted in several analogues fifty to a hundred fold more potent than cryptolepine.
A Facile Synthesis of 7-Halo-5H-indenopyridines and -pyridin-5-ones
DuPriest, Mark T.,Schmidt, Charles L.,Kuzmich, Daniel,Williams, Stanly B
, p. 2021 - 2023 (2007/10/02)
The 2-aryl-3-methylpyridines 7a-c were obtained in good yield by the addition of the corresponding aryllithium to 2-fluoro-3-methylpyridine.Permanganate oxidation provided the 2-aryl-3-pyridinecarboxylic acids 8a-c which were cyclized to 5H-indenopyridin-5-ones 6a-c in hot polyphosphoric acid.The 5H-indenopyridines 5a-c were readily obtained from the ketones 6a-c by treatment with hydrazine in hot diethylene glycol.
